Browsing Artikel in Fachzeitschriften by Author "Wagenführ, Katja"

Now showing items 1-9 of 9

2013-06-01Zeitschriftenartikel

BSE-associated Prion-Amyloid Cardiomyopathy in Primates

Krasemann, Susanne; Mearini, Giulia; Krämer, Elisabeth; Wagenführ, Katja; Schulz-Schaeffer, Walter; Neumann, Melanie; Bodemer, Walter; Kaup, Franz-Josef; Beekes, Michael; Carrier, Lucie; Aguzzi, Adriano; Glatzel, Markus

Prion amyloidosis occurred in the heart of 1 of 3 macaques intraperitoneally inoculated with bovine spongiform encephalopathy prions. This macaque had a remarkably long duration of disease and signs of cardiac distress. ...
2021-05-06Zeitschriftenartikel

Correction to: Transmissible α‑synuclein seeding activity in brain and stomach of patients with Parkinson’s disease

Thomzig, Achim; Wagenführ, Katja; Pinder, Phillip; Joncic, Marion; Schulz-Schaeffer, Walter J.; Beekes, Michael
2014-10-25Zeitschriftenartikel

Decontamination of medical devices from pathological amyloid-β-, tau- and α-synuclein aggregates

Thomzig, Achim; Wagenführ, Katja; Daus, Martin L.; Joncic, Marion; Schulz-Schaeffer, Walter J.; Thanheiser, Marc; Mielke, Martin; Beekes, Michael
2012-01-01Zeitschriftenartikel

Harnessing prions as test agents for the development of broad-range disinfectants

Wagenführ, Katja; Beekes, Michael

The development of disinfectants with broad-range efficacy against bacteria, viruses, fungi, protozoa and prions constitutes an ongoing challenge. Prions, the causative agents of transmissible spongiform encephalopathies ...
2022-10-07Zeitschriftenartikel

Kinetics of the reduction of Creutzfeldt–Jakob disease prion seeding activity by steam sterilization support the use of validated 134°C programmes

Schwenke, Karla A.; Wagenführ, Katja; Thanheiser, Marc; Beekes, Michael

Background Prions are renowned for their distinct resistance to chemical or physical inactivation, including steam sterilization. Impaired efficacy of inactivation poses a risk to patients for iatrogenic transmission ...
2011-04-01Zeitschriftenartikel

Presence and seeding activity of pathological prion protein (PrP(TSE)) in skeletal muscles of white-tailed deer infected with chronic wasting disease.

Daus, Martin L.; Breyer, Johanna; Wagenführ, Katja; Wemheuer, Wiebke M.; Thomzig, Achim; Schulz-Schaeffer, Walter; Beekes, Michael

Chronic wasting disease (CWD) is a contagious, rapidly spreading transmissible spongiform encephalopathy (TSE), or prion disease, occurring in cervids such as white tailed-deer (WTD), mule deer or elk in North America. ...
2011-05-27Zeitschriftenartikel

Quantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection.

Pritzkow, Sandra; Wagenführ, Katja; Daus, Martin L.; Boerner, Susann; Lemmer, Karin; Thomzig, Achim; Mielke, Martin; Beekes, Michael

Prions are pathogens with an unusually high tolerance to inactivation and constitute a complex challenge to the re-processing of surgical instruments. On the other hand, however, they provide an informative paradigm which ...
2013-03-11Zeitschriftenartikel

Towards further reduction and replacement of animal bioassays in prion research by cell and protein misfolding cyclic amplification assays

Boerner, Susann; Wagenführ, Katja; Daus, Martin L.; Thomzig, Achim; Beekes, Michael

Laboratory animals have long since been used extensively in bioassays for prions in order to quantify, usually in terms of median infective doses [ID50], how infectious these pathogens are in vivo. The identification of ...
2021-04-24Zeitschriftenartikel

Transmissible α-synuclein seeding activity in brain and stomach of patients with Parkinson’s disease

Thomzig, Achim; Wagenführ, Katja; Pinder, Phillip; Joncic, Marion; Schulz-Schaeffer, Walter J.; Beekes, Michael

Cerebral deposition of abnormally aggregated α-synuclein (αSyn) is a neuropathological hallmark of Parkinson’s disease (PD). PD-associated αSyn (αSynPD) aggregates can act as proteinaceous nuclei (“seeds”) able of ...