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Auflistung Artikel in Fachzeitschriften nach Autor "Dorner, Martin B."
Anzeige der Publikationen 1-8 von 8
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2018-05-02ZeitschriftenartikelA lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency Stern, Daniel; Weisemann, Jasmin; Le Blanc, Alexander; von Berg, Laura; Mahrhold, Stefan; Piesker, Janett; Laue, Michael; Luppa, Peter B.; Dorner, Martin B.; Dorner, Brigitte G.; Rummel, AndreasThe exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. ...
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2018-08-01ZeitschriftenartikelBotulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities Sikorra, Stefan; Skiba, Martin; Dorner, Martin B.; Weisemann, Jasmin; Weil, Mirjam; Valdezate, Sylvia; Davletov, Bazbek; Rummel, Andreas; Dorner, Brigitte G.; Binz, ThomasIn the recent past, about 40 botulinum neurotoxin (BoNT) subtypes belonging to serotypes A, B, E, and F pathogenic to humans were identified among hundreds of independent isolates. BoNTs are the etiological factors of ...
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2022-02-02ZeitschriftenartikelConstruction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid Nowakowska, Maria B.; Selby, Katja; Przykopanski, Adina; Krüger, Maren; Krez, Nadja; Dorner, Brigitte G.; Dorner, Martin B.; Jin, Rongsheng; Minton, Nigel P.; Rummel, Andreas; Lindström, MiiaBotulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a ...
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2023-01-18ZeitschriftenartikelCrystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1 Gao, Linfeng; Lam, Kwok-ho; Liu, Shun; Przykopanski, Adina; Lübke, Johanna; Qi, Ruifeng; Krüger, Maren; Nowakowska, Maria B.; Selby, Katja; Douillard, François P.; Dorner, Martin B.; Perry, Kay; Linström, Miia; Dorner, Brigitte G.; Rummel, Andreas; Jin, RongshengBotulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A–G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. The ...
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2021-04-18ZeitschriftenartikelDifferentiation, Quantification and Identification of Abrin and Abrus precatorius Agglutinin Worbs, Sylvia; Kampa, Bettina; Skiba, Martin; Hansbauer, Eva-Maria; Stern, Daniel; Volland, Hervé; Becher, François; Simon, Stéphanie; Dorner, Martin B.; Dorner, Brigitte G.Abrin, the toxic lectin from the rosary pea plant Abrus precatorius, has gained considerable interest in the recent past due to its potential malevolent use. However, reliable and easy-to-use assays for the detection and ...
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2019-04-02ZeitschriftenartikelFunctional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology von Berg, Laura; Stern, Daniel; Pauly, Diana; Mahrhold, Stefan; Weisemann, Jasmin; Jentsch, Lisa; Hansbauer, Eva-Maria; Müller, Christian; Avondet, Marc A.; Rummel, Andreas; Dorner, Martin B.; Dorner, Brigitte G.Botulinum neurotoxins (BoNTs) are the most potent toxins known and cause the life threatening disease botulism. Sensitive and broad detection is extremely challenging due to the toxins’ high potency and molecular heterogeneity ...
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2021-04-08ZeitschriftenartikelInnovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies Neumann, Thea; Krüger, Maren; Weisemann, Jasmin; Mahrhold, Stefan; Stern, Daniel; Dorner, Martin B.; Feraudet-Tarisse, Cécile; Pöhlmann, Christopher; Schulz, Katharina; Messelhäußer, Ute; Rimek, Dagmar; Gessler, Frank; Elßner, Thomas; Simon, Stéphanie; Rummel, Andreas; Dorner, Brigitte G.Clostridium perfringens enterotoxin (CPE) regularly causes food poisoning and antibioticassociated diarrhea; therefore, reliable toxin detection is crucial. To this aim, we explored stationary and mobile strategies to ...
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2018-06-26ZeitschriftenartikelReplacing the mouse bioassay for diagnostics and potency testing of botulinum neurotoxins – progress and challenges Stern, Daniel; von Berg, Laura; Skiba, Martin; Dorner, Martin B.; Dorner, Brigitte G.Botulinum neurotoxins (BoNTs) are the most potent toxins known and the causative agents of the rare but potentially life-threatening disease botulism. The elaborate mode of action of BoNTs at the molecular level, their ...