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Browsing Artikel in Fachzeitschriften by Author "Tappe, Dennis"
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2021-05ZeitschriftenartikelActive Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020 Eisermann, Philip; Rubbenstroth, Dennis; Cadar, Daniel; Thomé-Bolduan, Corinna; Eggert, Petra; Schlaphof, Alexander; Leypoldt, Frank; Stangel, Martin; Fortwängler, Thorsten; Hoffmann, Florian; Ostermann, Andreas; Zange, Sabine; Niller, Hans-Helmut; Angstwurm, Klemens; Pörtner, Kirsten; Frank, Christina; Wilking, Hendrik; Beer, Martin; Schmidt-Chanasit, Jonas; Tappe, DennisHuman bornavirus encephalitis is a severe and often fatal infection caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1). We conducted a prospective study of bornavirus etiology of ...
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2019-02-21ZeitschriftenartikelAnalysis of exotic squirrel trade and detection of human infections with variegated squirrel bornavirus 1, Germany, 2005 to 2018 Tappe, Dennis; Frank, Christina; Homeier-Bachmann, Timo; Wilking, Hendrik; Allendorf, Valerie; Schlottau, Kore; Muñoz-Fontela, César; Rottstegge, Monika; Port, Julia R.; Rissland, Jürgen; Eisermann, Philip; Beer, Martin; Schmidt-Chanasit, JonasFollowing the discovery in 2015 of the variegated squirrel bornavirus 1 (VSBV-1) in fatal encephalitis cases among exotic squirrel breeders and a zoo animal caretaker in Germany, a case definition was developed. It was ...
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2019-12-13ZeitschriftenartikelBornavirus-Infektionen: Hohe Letalität durch fulminante Meningoenzephalitiden Pörtner, Kirsten; Frank, Christina; Schmidt-Chanasit, Jonas; Beer, Martin; Rubbenstroth, Dennis; Tappe, Dennis
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2024-07-19ZeitschriftenartikelClinical analysis of Bornavirus Encephalitis cases demonstrates a small time window for Etiological Diagnostics and treatment attempts, a large case series from Germany 1996–2022 Pörtner, Kirsten; Wilking, Hendrik; Frank, Christina; Stark, Klaus; Wunderlich, Silke; Tappe, DennisPurpose: The emerging zoonotic Borna disease virus 1 (BoDV-1) and the variegated squirrel bornavirus 1 (VSBV-1) cause severe and fatal human encephalitis in Germany. We conducted the first systematic clinical analysis ...
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2023-05-30ZeitschriftenartikelDetection of bornavirus-reactive antibodies and BoDV-1 RNA only in encephalitis patients from virus endemic areas: a comparative serological and molecular sensitivity, specificity, predictive value, and disease duration correlation study Allartz, Petra; Hotop, Sven-Kevin; Muntau, Birgit; Schlaphof, Alexander; Thomé-Bolduan, Corinna; Gabriel, Martin; Petersen, Nadine; Lintzel, Maren; Behrens, Christoph; Eggert, Petra; Pörtner, Kirsten; Steiner, Johann; Brönstrup, Mark; Tappe, DennisPurpose: Human Borna disease virus (BoDV-1) encephalitis is an emerging disease in Germany. This study investigates the spectrum of human BoDV-1 infection, characterizes anti-BoDV-1-antibodies and kinetics, and compares ...
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2023-07-10ZeitschriftenartikelEx vivo infection model for Francisella using human lung tissue Köppen, Kristin; Fatykhova, Diana; Holland, Gudrun; Rauch, Jessica; Tappe, Dennis; Graff, Mareike; Rydzewski, Kerstin; Hocke, Andreas C.; Hippenstiel, Stefan; Heuner, KlausIntroduction: Tularemia is mainly caused by Francisella tularensis (Ft) subsp. tularensis (Ftt) and Ft subsp. holarctica (Ftt) in humans and in more than 200 animal species including rabbits and hares. Human clinical ...
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2023-02-23ZeitschriftenartikelFirst detected geographical cluster of BoDV-1 encephalitis from same small village in two children: therapeutic considerations and epidemiological implications Grosse, Leonie; Lieftüchter, Victoria; Vollmuth, Yannik; Hoffmann, Florian; Olivieri, Martin; Reiter, Karl; Tacke, Moritz; Heinen, Florian; Borggraefe, Ingo; Ostermann, Andreas; Forstner, Maria; Hübner, Johannes; von Both, Ulrich; Birzele, Lena; Rohlfs, Meino; Schomburg, Adrian; Böhmer, Merle M.; Ruf, Viktoria; Cadar, Dániel; Muntau, Birgit; Pförtner, Kirsten; Tappe, DennisBackground: The Borna disease virus (BoDV-1) is an emerging zoonotic virus causing severe and mostly fatal encephalitis in humans. Methods and Results: A local cluster of fatal BoDV-1 encephalitis cases was detected ...
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2021-12-21ZeitschriftenartikelHuman Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany Frank, Christina; Wickel, Jonathan; Brämer, Dirk; Matschke, Jakob; Ibe, Richard; Gazivoda, Caroline; Günther, Albrecht; Hartmann, Christian; Rehn, Kordt; Cadar, Daniel; Mayer, Thomas E.; Pörtner, Kirsten; Wilking, Hendrik; Schmidt-Chanasit, Jonas; Tappe, DennisIn 2021, three encephalitis cases due to the Borna disease virus 1 (BoDV-1) were diagnosed in the north and east of Germany. The patients were from the states of Thuringia, Saxony-Anhalt, and Lower Saxony. All were residents ...
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2022-07-27ZeitschriftenartikelHuman Borna disease virus 1 encephalitis shows marked pro-inflammatory biomarker and tissue immunoactivation during the course of disease Rauch, Jessica; Steffen, Johanna Friederike; Muntau, Birgit; Gisbrecht, Jana; Herden, Christiane; Bauswein, Markus; Rubbenstroth, Dennis; Mehlhoop, Ute; Allartz, Petra; Tappe, DennisHuman Borna disease virus 1 (BoDV-1) encephalitis is a severe emerging disease with a very high case-fatality rate. While the clinical disease, case definitions, diagnostic algorithms and neuropathology have been described, ...
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2021-08-10ZeitschriftenartikelInvestigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report Tappe, Dennis; Pörtner, Kirsten; Frank, Christina; Wilking, Hendrik; Ebinger, Arnt; Herden, Christiane; Schulze, Christoph; Muntau, Birgit; Eggert, Petra; Allartz, Petra; Schuldt, Gerlind; Schmidt-Chanasit, Jonas; Beer, Martin; Rubbenstroh, DennisBackground The true burden and geographical distribution of human Borna disease virus 1 (BoDV-1) encephalitis is unknown. All detected cases so far have been recorded in Bavaria, southern Germany. Case presentation A ...
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2024-09-10ZeitschriftenartikelLethal Borna disease virus 1 infections of humans and animals – in-depth molecular epidemiology and phylogeography Ebinger, Arnt; Santos, Pauline D.; Pfaff, Florian; Dürrwald, Ralf; Kolodziejek, Jolanta; Schlottau, Kore; Ruf, Viktoria; Liesche-Starnecker, Friederike; Ensser, Armin; Korn, Klaus; Ulrich, Reiner; Fürstenau, Jenny; Matiasek, Kaspar; Hansmann, Florian; Seuberlich, Torsten; Nobach, Daniel; Müller, Matthias; Neubauer-Juric, Antonie; Suchowski, Marcel; Bauswein, Markus; Niller, Hans-Helmut; Schmidt, Barbara; Tappe, Dennis; Cadar, Daniel; Homeier-Bachmann, Timo; Haring, Viola C.; Pörtner, Kirsten; Frank, Christina; Mundhenk, Lars; Hoffmann, Bernd; Herms, Jochen; Baumgärtner, Wolfgang; Nowotny, Norbert; Schlegel, Jürgen; Ulrich, Rainer G.; Beer, Martin; Rubbenstroth, DennisBorna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored ...
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2019-12-27ZeitschriftenartikelLow prevalence of Borna disease virus 1 (BoDV-1) IgG antibodies in humans from areas endemic for animal Borna disease of Southern Germany Tappe, Dennis; Frank, Christina; Offergeld, Ruth; Wagner-Wiening, Christiane; Stark, Klaus; Rubbenstroth, Dennis; Giese, Sebastian; Lattwein, Erik; Schwemmle, Martin; Schmidt-Chanasit, Jonas; Wilking, HendrikBorna disease virus-1 (BoDV-1) was recently discovered as cause of severe and often fatal encephalitis in humans. BoDV-1 is known to cause neurological disease in horses and sheep mainly in South and Central Germany. The ...
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2023-02-27ZeitschriftenartikelRisk factors for Borna disease virus 1 encephalitis in Germany – a case–control study Pörtner, Kirsten; Wilking, Hendrik; Frank, Christina; Böhmer, Merle M.; Stark, Klaus; Tappe, DennisIn 2018, Borna Disease Virus 1 (BoDV-1) was confirmed as a human zoonotic pathogen causing rare but fatal encephalitis in Germany. While diagnostic procedures and the clinical picture have been described, epidemiology ...
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2020-02-18ZeitschriftenartikelTravel-associated neurological disease terminated in a postmortem diagnosed atypical HSV-1 encephalitis after high-dose steroid therapy – a case report Osterman, Andreas; Ruf, Viktoria C.; Domingo, Christina; Nitsche, Andreas; Eichhorn, Peter; Zimmermann, Hanna; Seelos, Klaus; Zange, Sabine; Dimitriadis, Konstantinos; Pfister, Hans-Walter; Thye, Thorsten; Giese, Armin; Tappe, Dennis; Böhm, StephanBackground Human encephalitis can originate from a variety of different aetiologies, of which infection is the most common one. The diagnostic work-up is specifically challenging in patients with travel history since a ...