2016-06-16Zeitschriftenartikel
Only the complex N559-glycan in SV2C mediates high affinity binding to botulinum neurotoxin serotype A1
Mahrhold, Stefan; Bergström, Tomas; Stern, Daniel; Dorner, Brigitte; Astot, Crister; Rummel, Andreas
The extraordinary potency of botulinum neurotoxins (BoNTs) is mediated by their high neurospecificity, targeting peripheral cholinergic motoneurons leading to flaccid paralysis and successive respiratory failure. Complex ...