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Browsing Artikel in Fachzeitschriften by Author "Denner, Joachim"
Now showing items 21-40 of 66
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2017-01-12ZeitschriftenartikelEffective Detection of Porcine Cytomegalovirus Using Non-Invasively Taken Samples from Piglets Morozov, Vladimir A.; Heinrichs, Gerd; Denner, JoachimShortage of human organs forced the development of xenotransplantation using cells, tissues, and organs from pigs. Xenotransplantation may be associated with the transmission of porcine zoonotic microorganisms, among them ...
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2016-06-29ZeitschriftenartikelEfficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing Fischer, Konrad; Kraner-Scheiber, Simone; Petersen, Björn; Rieblinger, Beate; Buermann, Anna; Flisikowska, Tatiana; Flisikowski, Krzysztof; Christan, Susanne; Edlinger, Marlene; Baars, Wiebke; Kurome, Mayuko; Zakhartchenko, Valeri; Kessler, Barbara; Plotzki, Elena; Szczerbal, Izabela; Switonski, Marek; Denner, Joachim; Wolf, Eckhard; Schwinzer, Reinhard; Niemann, Heiner; Kind, Alexander; Schnieke, AngelikaXenotransplantation from pigs could alleviate the shortage of human tissues and organs for transplantation. Means have been identified to overcome hyperacute rejection and acute vascular rejection mechanisms mounted by the ...
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2020-11-19ZeitschriftenartikelEndogenous retroviruses expressed in human tumours cannot be used as targets for anti-tumour vaccines Denner, JoachimMany tumour cells express on their surface proteins of endogenous retroviruses (ERVs) and there are suggestions to use these retroviral antigens as target for anti-tumour vaccines. However, until now there is no convincing ...
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2014-03-19ZeitschriftenartikelExpression-analysis of the human endogenous retrovirus HERV-K in human astrocytic tumors Kessler, Almuth Friederike; Wiesner, Miriam; Denner, Joachim; Kämmerer, Ulrike; Vince, Giles Hamilton; Linsenmann, Thomas; Löhr, Mario; Ernestus, Ralf-Ingo; Hagemann, CarstenBackground: The human endogenous retrovirus K (HERV-K) has been acquired by the genome of human ancestors million years ago. It is the most complete of the HERVs with transcriptionally active gag, pol and env genes. ...
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2015-10-14ZeitschriftenartikelExtended Microbiological Characterization of Göttingen Minipigs in the Context of Xenotransplantation: Detection and Vertical Transmission of Hepatitis E Virus Morozov, Vladimir A.; Morozov, Alexey V.; Rotem, Avi; Barkai, Uriel; Bornstein, Stefan; Denner, JoachimXenotransplantation has been proposed as a solution to the shortage of suitable human donors. Pigs are currently favoured as donor animals for xenotransplantation of cells, including islet cells, or organs. To reduce the ...
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2019-03-13ZeitschriftenartikelHepatitis E virus (HEV)—The Future Denner, JoachimHepatitis (HEV) is widely distributed in pigs and is transmitted with increasing numbers to humans by contact with pigs, contaminated food and blood transfusion. The virus is mostly apathogenic in pigs but may enhance the ...
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2016-08-03ZeitschriftenartikelHow Active Are Porcine Endogenous Retroviruses (PERVs)? Denner, JoachimPorcine endogenous retroviruses (PERVs) represent a risk factor if porcine cells, tissues, or organs were to be transplanted into human recipients to alleviate the shortage of human transplants; a procedure called ...
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2011-08-15ZeitschriftenartikelHuman endogenous retrovirus K (HERV-K) is expressed in villous and extravillous cytotrophoblast cells of the human placenta Kämmerer, U.; Germeyer, A.; Stengel, Sven; Kapp, M.; Denner, JoachimHuman endogenous retroviruses (HERVs) have been shown to be important in physiological and pathophysiological processes in humans. Several HERVs have been found to be expressed in the placenta—a tissue with special ...
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2013-07-24ZeitschriftenartikelIdentification of the feline foamy virus Bet domain essential for APOBEC3 counteraction Lukic, Dragana Slavkovic; Hotz-Wagenblatt, Agnes; Lei, Janet; Räthe, Ann-Mareen; Mühle, Michael; Denner, Joachim; Münk, Carsten; Löchelt, MartinBackground: APOBEC3 (A3) proteins restrict viral replication by cytidine deamination of viral DNA genomes and impairing reverse transcription and integration. To escape this restriction, lentiviruses have evolved the ...
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2013-02-26ZeitschriftenartikelImmunisation with foamy virus Bet fusion proteins as novel strategy for HIV-1 epitope delivery Mühle, Michael; Hoffmann, Kerstin; Löchelt, Martin; Denner, JoachimThe induction of 2F5- and 4E10-like antibodies broadly neutralising HIV-1 and targeting the membrane external proximal region (MPER) of the transmembrane envelope protein gp41 would be a major advancement for the development ...
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2012-09-13ZeitschriftenartikelImmunisation with the membrane proximal external region of gp41 of HIV-1 grafted into the transmembrane envelope protein of a gammaretrovirus Strasz, N.; Morozov, Vladimir; Kreutzberger, J.; Lau, M.; Denner, Joachim
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2011-02-10ZeitschriftenartikelImmunological properties of the transmembrane envelope protein of the feline foamy virus and its use for serological screening Mühle, Michael; Bleiholder, Anne; Kolb, Susanne; Hübner, Janine; Löchelt, Martin; Denner, JoachimThe transmembrane envelope (TM) proteins of retroviruses are used as antigen in diagnostic immunoassays and they represent a conserved target for neutralizing antibodies. To analyze the situation in infections with the ...
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2020-10-16ZeitschriftenartikelImpact of porcine cytomegalovirus on long‑term orthotopic cardiac xenotransplant survival Denner, Joachim; Längin, Matthias; Reichart, Bruno; Krüger, Luise; Fiebig, Uwe; Mokelke, Maren; Radan, Julia; Mayr, Tanja; Milusev, Anastasia; Luther, Fabian; Sorvillo, Nicoletta; Rieben, Robert; Brenner, Paolo; Walz, Christoph; Wolf, Eckhard; Roshani, Berit; Stahl‑Hennig, Christiane; Abicht, Jan‑MichaelXenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic ...
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2012-11-05ZeitschriftenartikelIncreased titers of neutralizing antibodies after immunization with both envelope proteins of the porcine endogenous retroviruses (PERVs) Denner, Joachim; Mihica, Debora; Kaulitz, Danny; Schmidt, Christa-MariaDespite enormous difficulties to induce antibodies neutralizing HIV-1, especially broadly neutralizing antibodies directed against the conserved membrane proximal external region (MPER) of the transmembrane envelope protein, ...
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2012-08-22ZeitschriftenartikelInduction of Antibodies Specific for Gp41 of HIV-1 by Gene Gun DNA Vaccination Behrendt, Rayk; Fiebig, Uwe; Schmolke, Mirco; Kurth, Reinhard; Denner, JoachimAll attempts to induce broadly neutralising antibodies such as mAb 2F5 and mAb 4E10 targeting conserved epitopes in the membrane proximal external region (MPER) of the transmembrane envelope (TM) protein gp41 of HIV-1 ...
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2005-12-08ZeitschriftenartikelInduction of HIV-neutralising Antibodies of the 2F5/4E10 Type Fiebig, Uwe; Langhammer, Stefan; Kurth, Reinhard; Denner, Joachim
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2015-04-30ZeitschriftenartikelInduction of neutralizing antibodies specific for the envelope proteins of the koala retrovirus by immunization with recombinant proteins or with DNA Fiebig, Uwe; Dieckhoff, Britta; Wurzbacher, Christian; Möller, Annekathrin; Kurth, Reinhard; Denner, JoachimBackground: The koala retrovirus (KoRV) is the result of a transspecies transmission of a gammaretrovirus with fatal consequences for the new host. Like many retroviruses, KoRV induces lymphoma, leukemia and an ...
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2012-04-01ZeitschriftenartikelInfection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous Retroviruses Denner, Joachim; Tönjes, Ralf R.Xenotransplantation may be a solution to overcome the shortage of organs for the treatment of patients with organ failure, but it may be associated with the transmission of porcine microorganisms and the development of ...
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2008-03-10ZeitschriftenartikelKnockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs Dieckhoff, Britta; Petersen, Björn; Kues, Wilfried A.; Kurth, Reinhard; Niemann, Heiner; Denner, JoachimBackground: Xenotransplantation using porcine cells, tissues or organs may be associated with the transmission of porcine endogenous retroviruses (PERVs). More than 50 viral copies have been identified in the pig genome ...
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2013-10-23ZeitschriftenartikelKoala retroviruses: characterization and impact on the life of koalas Denner, Joachim; Young, Paul R.Koala retroviruses (KoRV) have been isolated from wild and captive koalas in Australia as well as from koala populations held in zoos in other countries. They are members of the genus Gammaretrovirus, are most closely ...