Browsing Artikel in Fachzeitschriften by Author "Gruber, Achim D."

Now showing items 1-5 of 5

2020-03-12Zeitschriftenartikel

Adeno‐associated virus‐vectored influenza vaccine elicits neutralizing and Fcγ receptor‐activating antibodies

Demminger, Daniel E.; Walz, Lisa; Dietert, Kristina; Hoffmann, Helen; Planz, Oliver; Gruber, Achim D.; von Messling, Veronika; Wolff, Thorsten

The current seasonal inactivated influenza vaccine protects only against a narrow range of virus strains as it triggers a dominant antibody response toward the hypervariable hemagglutinin (HA) head region. The discovery ...
2007-05-01Zeitschriftenartikel

Leptospirosis in urban wild boars, Berlin, Germany.

Jansen, Andreas; Luge, Enno; Guerra, Beatriz; Wittschen, Petra; Gruber, Achim D.; Loddenkemper, Christoph; Schneider, Thomas; Lierz, Michael; Ehlert, Derk; Appel, Bernd; Stark, Klaus; Nöckler, Karsten

We found antibodies to leptospires in 25 (18%) of 141 wild boars from Berlin (95% confidence interval 12-25). Seropositivity was associated with chronic interstitial nephritis (odds ratio 10.5; p=0.01), and leptospires ...
2013-02-28Zeitschriftenartikel

Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

Högner, Katrin; Wolff, Thorsten; Pleschka, Stephan; Plog, Stephanie; Gruber, Achim D.; Kalinke, Ulrich; Walmrath, Hans-Dieter; Bodner, Johannes; Gattenlöhner, Stefan; Lewe-Schlosser, Peter; Matrosovich, Mikhail; Seeger, Werner; Lohmeyer, Jürgen; Herold, Susanne

Influenza viruses (IV) cause pneumonia in humans with progression to lung failure and fatal outcome. Dysregulated release of cytokines including type I interferons (IFNs) has been attributed a crucial role in immune-mediated ...
2013-10-08Zeitschriftenartikel

The Novel Human Influenza A(H7N9) Virus Is Naturally Adapted to Efficient Growth in Human Lung Tissue

Knepper, Jessica; Schierhorn, Kristina L.; Becher, Anne; Budt, Matthias; Tönnies, Mario; Bauer, Torsten T.; Schneider, Paul; Neudecker, Jens; Rückert, Jens C.; Gruber, Achim D.; Suttorp, Norbert; Schweiger, Brunhilde; Hippenstiel, Stefan; Hocke, Andreas C.; Wolff, Thorsten

A novel influenza A virus (IAV) of the H7N9 subtype has been isolated from severely diseased patients with pneumonia and acute respiratory distress syndrome and, apparently, from healthy poultry in March 2013 in Eastern ...
2010-08-04Zeitschriftenartikel

Virulence Determinants of Avian H5N1 Influenza A Virus in Mammalian and Avian Hosts: Role of the C-Terminal ESEV Motif in the Viral NS1 Protein

Zielecki, Florian; Semmler, Ilia; Kalthoff, Donata; Voss, Daniel; Mauel, Susanne; Gruber, Achim D.; Beer, Martin; Wolff, Thorsten

We assessed the prediction that access of the viral NS1 protein to cellular PDZ domain protein networks enhances the virulence of highly pathogenic avian influenza A viruses. The NS1 proteins of most avian influenza viruses ...