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2009-10-27Zeitschriftenartikel DOI: 10.3390/v1030523
Activation of the Antiviral Kinase PKR and Viral Countermeasures
dc.contributor.authorDauber, Bianca
dc.contributor.authorWolff, Thorsten
dc.date.accessioned2018-05-07T13:21:46Z
dc.date.available2018-05-07T13:21:46Z
dc.date.created2009-11-03
dc.date.issued2009-10-27none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rectxlDXpq9jE/PDF/23r0KrcYzLRw.pdf
dc.identifier.urihttp://edoc.rki.de/176904/472
dc.description.abstractThe interferon-induced double-stranded (ds)RNA-dependent protein kinase (PKR) limits viral replication by an eIF2-mediated block of translation. Although many negative-strand RNA viruses activate PKR, the responsible RNAs have long remained elusive, as dsRNA, the canonical activator of PKR, has not been detected in cells infected with such viruses. In this review we focus on the activating RNA molecules of different virus families, in particular the negative-strand RNA viruses. We discuss the recently identified non-canonical activators 5’-triphosphate RNA and the vRNP of influenza virus and give an update on strategies of selected RNA and DNA viruses to prevent activation of PKR.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectPKReng
dc.subjectviruseng
dc.subjectdsRNAeng
dc.subjectinnate immunityeng
dc.subjectimmune evasioneng
dc.subject.ddc610 Medizin
dc.titleActivation of the Antiviral Kinase PKR and Viral Countermeasures
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1002722
dc.identifier.doi10.3390/v1030523
dc.identifier.doihttp://dx.doi.org/10.25646/397
local.edoc.container-titleViruses
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.mdpi.com/1999-4915/1/3/523
local.edoc.container-publisher-namempdi

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