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2008-07-23Zeitschriftenartikel DOI: 10.1371/journal.pone.0002747
CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual
dc.contributor.authorOh, Djin-Ye
dc.contributor.authorJessen, Heiko
dc.contributor.authorKücherer, Claudia
dc.contributor.authorNeumann, Konrad
dc.contributor.authorOh, Nari
dc.contributor.authorPoggensee, Gabriele
dc.contributor.authorBartmeyer, Barbara
dc.contributor.authorJessen, Arne
dc.contributor.authorPruss, Axel
dc.contributor.authorSchumann, Ralf R.
dc.contributor.authorHamouda, Osamah
dc.date.accessioned2018-05-07T13:22:53Z
dc.date.available2018-05-07T13:22:53Z
dc.date.created2009-11-09
dc.date.issued2008-07-23none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/regN22ZePO96/PDF/23WUBq6ygEjys.pdf
dc.identifier.urihttp://edoc.rki.de/176904/478
dc.description.abstractBackground: Homozygosity (Δ32/Δ32) for the 32 bp deletion in the chemokine receptor 5 (CCR5) gene is associated with strong resistance against HIV infection. Heterozygosity is associated with protection of HIV-1 disease progression. Methodology/Principal Findings: We genotyped a population of 737 HIV-positive adults and 463 healthy controls for the CCR5Δ32 deletion and found heterozygous frequencies of 16.2% (HIV-negative) and 17.5% (HIV-positive) among Caucasian individuals. Analysis of CCR5Δ32 influence on disease progression showed notably lower viral setpoints and a longer time to a CD4 count ofeng
dc.language.isoeng
dc.publisherRobert Koch-Institut; Robert Koch-Institut, Infektionsepidemiologie
dc.subjectHumanseng
dc.subjectAdulteng
dc.subjectGermanyeng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectMutationeng
dc.subjectCohort Studieseng
dc.subjectDisease Progressioneng
dc.subjectGenotypeeng
dc.subjectHIV Infections/bloodeng
dc.subjectHIV Infections/geneticseng
dc.subjectHIV Seropositivity/geneticseng
dc.subjectHIV-1/metabolismeng
dc.subjectHeterozygoteeng
dc.subjectHomozygoteeng
dc.subjectReceptorseng
dc.subjectCCR5/geneticseng
dc.subjectCCR5/physiologyeng
dc.subject.ddc610 Medizin
dc.titleCCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1002838
dc.identifier.doi10.1371/journal.pone.0002747
dc.identifier.doihttp://dx.doi.org/10.25646/403
local.edoc.container-titlePLoS One
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/
local.edoc.container-publisher-namePLoS
local.edoc.container-volume3
local.edoc.container-issue7
local.edoc.container-year2008

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