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2008-11-21Zeitschriftenartikel DOI: 10.1017/S0950268808001465
Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H− causes another outbreak of haemolytic uraemic syndrome in children
dc.contributor.authorAlpers, Katharina
dc.contributor.authorWerber, Dirk
dc.contributor.authorFrank, Christina
dc.contributor.authorKoch, Judith
dc.contributor.authorFriedrich, Alexander W.
dc.contributor.authorKarch, Helge
dc.contributor.authorHeiden, Matthias an der
dc.contributor.authorPrager, Rita
dc.contributor.authorFruth, Angelika
dc.contributor.authorBielaszewska, Martina
dc.contributor.authorMorlock, Gabi
dc.contributor.authorHeissenhuber, A.
dc.contributor.authorDiedler, A.
dc.contributor.authorGerber, A.
dc.contributor.authorAmmon, Andrea
dc.date.accessioned2018-05-07T13:35:53Z
dc.date.available2018-05-07T13:35:53Z
dc.date.created2010-01-18
dc.date.issued2008-11-21none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/repqtrPRFkqxk/PDF/264XtIsFlLrk.pdf
dc.identifier.urihttp://edoc.rki.de/176904/548
dc.description.abstractAn outbreak of haemolytic uraemic syndrome (HUS) among children caused by infection with sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- (SF EHEC O157:H-) occurred in Germany in 2002. This pathogen has caused several outbreaks so far, yet its reservoir and routes of transmission remain unknown. SF EHEC O157:H- is easily missed as most laboratory protocols target the more common sorbitol non-fermenting strains. We performed active case-finding, extensive exploratory interviews and a case-control study. Clinical and environmental samples were screened for SF EHEC O157:H- and the isolates were subtyped by pulsed-field gel electrophoresis. We identified 38 case-patients in 11 federal states. Four case-patients died during the acute phase (case-fatality ratio 11%). The case-control study could not identify a single vehicle or source. Further studies are necessary to identify the pathogen's reservoir(s). Stool samples of patients with HUS should be tested with an adequate microbiological set-up to quickly identify SF EHEC O157:H-.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectHumanseng
dc.subjectPreschooleng
dc.subjectFemaleeng
dc.subjectDisease Outbreakseng
dc.subjectGermany/epidemiologyeng
dc.subjectMaleeng
dc.subjectChildeng
dc.subjectCase-Control Studieseng
dc.subjectFood Microbiologyeng
dc.subjectInfanteng
dc.subjectLogistic Modelseng
dc.subjectFood Contaminationeng
dc.subjectHemolytic-Uremic Syndrome/microbiologyeng
dc.subjectHemolytic-Uremic Syndrome/epidemiologyeng
dc.subjectFoodborne Diseases/epidemiologyeng
dc.subjectEscherichia coli O157/isolation & purificationeng
dc.subjectEscherichia coli O157/metabolismeng
dc.subjectFoodborne Diseases/microbiologyeng
dc.subjectSorbitol/metabolismeng
dc.subject.ddc610 Medizin
dc.titleSorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H− causes another outbreak of haemolytic uraemic syndrome in children
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1003836
dc.identifier.doi10.1017/S0950268808001465
dc.identifier.doihttp://dx.doi.org/10.25646/473
local.edoc.container-titleEpidemiology and Infection
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=3650312
local.edoc.container-publisher-nameCambridge University Press
local.edoc.container-volume137
local.edoc.container-year2009

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