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2017-11-24Zeitschriftenartikel DOI: 10.25646/5671
AureoWiki ̵ The repository of the Staphylococcus aureus research and annotation community
dc.contributor.authorFuchs, Stephan
dc.contributor.authorMehlan, Henry
dc.contributor.authorBernhardt, Jörg
dc.contributor.authorHennig, André
dc.contributor.authorMichalik, Stephan
dc.contributor.authorSurmann, Kristin
dc.contributor.authorPané-Farré, Jan
dc.contributor.authorGiese, Anne
dc.contributor.authorWeiss, Stefan
dc.contributor.authorBackert, Linus
dc.contributor.authorHerbig, Alexander
dc.contributor.authorNieselt, Kay
dc.contributor.authorHecker, Michael
dc.contributor.authorVölker, Uwe
dc.contributor.authorMäder, Ulrike
dc.date.accessioned2018-09-12T06:17:51Z
dc.date.available2018-09-12T06:17:51Z
dc.date.issued2017-11-24none
dc.identifier.other10.1016/j.ijmm.2017.11.011
dc.identifier.urihttp://edoc.rki.de/176904/5736
dc.description.abstractIn light of continuously accumulating data and knowledge on major human pathogens, comprehensive and up-to-date sources of easily accessible information are urgently required. The AureoWiki database (http://aureowiki.med.uni-greifswald.de) provides detailed information on the genes and proteins of clinically and experimentally relevant S. aureus strains, currently covering NCTC 8325, COL, Newman, USA300_FPR3757, and N315. By implementing a pan-genome approach, AureoWiki facilitates the transfer of knowledge gained in studies with different S. aureus strains, thus supporting functional annotation and better understanding of this organism. All data related to a given gene or gene product is compiled on a strain-specific gene page. The gene pages contain sequence-based information complemented by data on, for example, protein function and localization, transcriptional regulation, and gene expression. The information provided is connected via links to other databases and published literature. Importantly, orthologous genes of the individual strains, which are linked by a pan-genome gene identifier and a unified gene name, are presented side by side using strain-specific tabs. The respective pan-genome gene page contains an orthologue table for 32 S. aureus strains, a multiple-strain genome viewer, a protein sequence alignment as well as other comparative information. The data collected in AureoWiki is also accessible through various download options in order to support bioinformatics applications. In addition, based on two large-scale gene expression data sets, AureoWiki provides graphical representations of condition-dependent mRNA levels and protein profiles under various laboratory and infection-related conditions.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de/
dc.subjectS. aureuseng
dc.subjectDatabaseeng
dc.subjectGene and protein informationeng
dc.subjectPan-genomeeng
dc.subjectUnified gene nameseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleAureoWiki ̵ The repository of the Staphylococcus aureus research and annotation communitynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5736-4
dc.identifier.doihttp://dx.doi.org/10.25646/5671
dc.type.versionpublishedVersionnone
local.edoc.container-titleInternational Journal of Medical Microbiologynone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/science/article/pii/S1438422117304629none
local.edoc.container-publisher-nameElseviernone
local.edoc.container-volume308none
local.edoc.container-issue6none
local.edoc.container-reportyear2018none
local.edoc.container-firstpage558none
local.edoc.container-lastpage568none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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