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2018-05-23Zeitschriftenartikel DOI: 10.25646/5685
HDV infection rates in northern Vietnam
dc.contributor.authorBinh, Mai Thanh
dc.contributor.authorHoan, Nghiem Xuan
dc.contributor.authorTong, Hoang Van
dc.contributor.authorGiang, Dao Phuong
dc.contributor.authorSy, Bui Tien
dc.contributor.authorToan, Nguyen Linh
dc.contributor.authorSong, Le Huu
dc.contributor.authorBang, Mai Hong
dc.contributor.authorWedemeyer, Heiner
dc.contributor.authorMeyer, Christian G.
dc.contributor.authorKremsner, Peter G.
dc.contributor.authorBock, Thomas
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.date.accessioned2018-09-12T15:01:19Z
dc.date.available2018-09-12T15:01:19Z
dc.date.issued2018-05-23none
dc.identifier.other10.1038/s41598-018-26446-w
dc.identifier.urihttp://edoc.rki.de/176904/5750
dc.description.abstractHepatitis D caused by the hepatitis delta virus (HDV) is a serious health problem in many regions of the world. A total of 546 HBV-infected patients were enrolled from 2013 to 2015 and classified clinically into the subgroups of chronic hepatitis B (CHB, n = 191), liver cirrhosis (LC, n = 147) and hepatocellular carcinoma (HCC, n = 208). The patients were screened for HDV-RNA by nested PCR assays. HDV genotypes were assessed by direct sequencing, followed by phylogenetic analysis. HDV-RNA was identified in 13% (71/546) of HBV-infected patients. The highest HDV prevalence was found in the LC group (19.7%), followed by the HCC (12%) and CHB (8.9%) groups (P = 0.017). HDV/HBV coinfections were significantly associated with a rather unfavourable clinical outcome, in particular with LC development compared to HBV monoinfection. Phylogenetic analyses indicated that the genotype HDV1 was, with a prevalence of 91%, by far the most common genotype in Vietnam, followed by HDV2 with 9%. Other HDV genotypes were not observed. In accordance with previous data obtained a decade ago, our results confirm a continuing high prevalence of HDV infection in hepatitis B patients in northern Vietnam with the HDV1 genotype still being the predominant genotype. HDV nucleic acid testing to minimize the associated risk should be considered.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleHDV infection rates in northern Vietnamnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5750-1
dc.identifier.doihttp://dx.doi.org/10.25646/5685
dc.type.versionpublishedVersionnone
local.edoc.container-titleScientific Reportsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41598-018-26446-wnone
local.edoc.container-publisher-nameNature Publishing Groupnone
local.edoc.container-volume8none
local.edoc.container-issue8047none
local.edoc.container-firstpage1none
local.edoc.container-lastpage7none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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