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2018-10-23Zeitschriftenartikel DOI: 10.25646/5834
A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017
dc.contributor.authorWang, Bo
dc.contributor.authorAkanbi, Olusola Anuoluwapo
dc.contributor.authorHarms, Dominik
dc.contributor.authorAdesina, Olufisayo
dc.contributor.authorOsundare, Folakemi Abiodun
dc.contributor.authorNaidoo, Dhamari
dc.contributor.authorDeveaux, Isabel
dc.contributor.authorOgundiran, Opeayo
dc.contributor.authorUgochukwu, Uzoma
dc.contributor.authorMba, Nwando
dc.contributor.authorIhekweazu, Chikwe
dc.contributor.authorBock, Thomas
dc.date.accessioned2018-12-17T11:11:14Z
dc.date.available2018-12-17T11:11:14Z
dc.date.issued2018-10-23none
dc.identifier.other10.1186/s12985-018-1082-8
dc.identifier.urihttp://edoc.rki.de/176904/5883
dc.description.abstractBackground: In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail. Finding: The full-length genome sequence of an HEV-2 strain (NG/17–0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17–0500 belongs to HEV subtype 2b (HEV-2b). Conclusions: We identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectHepatitis E viruseng
dc.subjectHEV genotype 2eng
dc.subjectHEV subtype 2beng
dc.subjectOutbreakeng
dc.subjectNigeriaeng
dc.subjectComplete genomeeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleA new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017none
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5883-0
dc.identifier.doihttp://dx.doi.org/10.25646/5834
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirology Journalnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://virologyj.biomedcentral.com/articles/10.1186/s12985-018-1082-8none
local.edoc.container-publisher-nameBioMedCentralnone
local.edoc.container-volume15none
local.edoc.container-issue163none
local.edoc.container-reportyear2018none
local.edoc.container-firstpage1none
local.edoc.container-lastpage6none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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