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2019-01-31Zeitschriftenartikel DOI: 10.25646/5927
Molecular Evolution of Human Adenovirus (HAdV) Species C
dc.contributor.authorDhingra, Akshay
dc.contributor.authorHage, Elias
dc.contributor.authorGanzenmueller, Tina
dc.contributor.authorBöttcher, Sindy
dc.contributor.authorHofmann, Jörg
dc.contributor.authorHamprecht, Klaus
dc.contributor.authorObermeier, Patrick
dc.contributor.authorRath, Barbara
dc.contributor.authorHausmann, Fabian
dc.contributor.authorDobner, Thomas
dc.contributor.authorHeim, Albert
dc.date.accessioned2019-03-05T09:47:25Z
dc.date.available2019-03-05T09:47:25Z
dc.date.issued2019-01-31none
dc.identifier.other10.1038/s41598-018-37249-4
dc.identifier.urihttp://edoc.rki.de/176904/5962
dc.description.abstractCurrently, 88 different Human Adenovirus (HAdV) types are grouped into seven HAdV species A to G. Most types (57) belong to species HAdV-D. Recombination between capsid genes (hexon, penton and fiber) is the main factor contributing to the diversity in species HAdV-D. Noteworthy, species HAdV-C contains so far only five types, although species HAdV-C is highly prevalent and clinically significant in immunosuppressed patients. Therefore, the evolution of species HAdV-C was studied by generating 51 complete genome sequences from circulating strains. Clustering of the whole genome HAdV-C sequences confirmed classical typing results (fifteen HAdV-C1, thirty HAdV-C2, four HAdV-C5, two HAdV-C6). However, two HAdV-C2 strains had a novel penton base sequence and thus were re-labeled as the novel type HAdV-C89. Fiber and early gene region 3 (E3) sequences clustered always with the corresponding prototype sequence but clustering of the E4 region indicated recombination events in 26 out of the 51 sequenced specimens. Recombination of the E1 gene region was detected in 16 circulating strains. As early gene region sequences are not considered in the type definition of HAdVs, evolution of HAdV-C remains on the subtype level. Nonetheless, recombination of the E1 and E4 gene regions may influence the virulence of HAdV-C strains.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleMolecular Evolution of Human Adenovirus (HAdV) Species Cnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5962-4
dc.identifier.doihttp://dx.doi.org/10.25646/5927
dc.type.versionpublishedVersionnone
local.edoc.container-titleScientific Reportsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41598-018-37249-4none
local.edoc.container-publisher-nameNature Publishing Groupnone
local.edoc.container-volume2019none
local.edoc.container-issue9none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage13none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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