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2019-02-07Zeitschriftenartikel DOI: 10.25646/5948
Absence of adaptive evolution is the main barrier against influenza emergence in horses in Asia despite frequent virus interspecies transmission from wild birds
dc.contributor.authorZhu, Henan
dc.contributor.authorDamdinjav, Batchuluun
dc.contributor.authorGonzalez, Gaelle
dc.contributor.authorPatrono, Livia V.
dc.contributor.authorRamirez-Mendoza, Humberto
dc.contributor.authorAmat, Julien A. R.
dc.contributor.authorCrispell, Joanna
dc.contributor.authorParr, Yasmin Amy
dc.contributor.authorHammond, Toni-ann
dc.contributor.authorShiilegdamba, Enkhtuvshin
dc.contributor.authorLeung, Y. H. Connie
dc.contributor.authorPeiris, Malik
dc.contributor.authorMarshall, John F.
dc.contributor.authorHughes, Joseph
dc.contributor.authorGilbert, Martin
dc.contributor.authorMurcia, Pablo R.
dc.date.accessioned2019-03-14T10:10:42Z
dc.date.available2019-03-14T10:10:42Z
dc.date.issued2019-02-07none
dc.identifier.other10.1371/journal.ppat.1007531
dc.identifier.urihttp://edoc.rki.de/176904/5983
dc.description.abstractVirus ecology and evolution play a central role in disease emergence. However, their relative roles will vary depending on the viruses and ecosystems involved. We combined field studies, phylogenetics and experimental infections to document with unprecedented detail the stages that precede initial outbreaks during viral emergence in nature. Using serological surveys we showed that in the absence of large-scale outbreaks, horses in Mongolia are routinely exposed to and infected by avian influenza viruses (AIVs) circulating among wild birds. Some of those AIVs are genetically related to an avian-origin virus that caused an epizootic in horses in 1989. Experimental infections showed that most AIVs replicate in the equine respiratory tract without causing lesions, explaining the absence of outbreaks of disease. Our results show that AIVs infect horses but do not spread, or they infect and spread but do not cause disease. Thus, the failure of AIVs to evolve greater transmissibility and to cause disease in horses is in this case the main barrier preventing disease emergence.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectHorseseng
dc.subjectInfluenza A viruseng
dc.subjectBird genomicseng
dc.subjectAnimal phylogeneticseng
dc.subjectEquineseng
dc.subjectInfluenza viruseng
dc.subjectAvian influenzaeng
dc.subjectMongoliaeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleAbsence of adaptive evolution is the main barrier against influenza emergence in horses in Asia despite frequent virus interspecies transmission from wild birdsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5983-1
dc.identifier.doihttp://dx.doi.org/10.25646/5948
dc.type.versionpublishedVersionnone
local.edoc.container-titlePLoS Pathogensnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007531none
local.edoc.container-publisher-namePublic Library of Sciencenone
local.edoc.container-volume2019none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage23none
local.edoc.rki-departmentProjektgruppen/Nachwuchsgruppennone
dc.description.versionPeer Reviewednone

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