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2019-02-26Zeitschriftenartikel DOI: 10.25646/5975
Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection
dc.contributor.authorSouza, Thiago Moreno L.
dc.contributor.authorRangel Vieira, Yasmine
dc.contributor.authorDelatorre, Edson
dc.contributor.authorBarbosa-Lima, Giselle
dc.contributor.authorLuiz, Raul Leal Faria
dc.contributor.authorVizzoni, Alexandre
dc.contributor.authorJain, Komal
dc.contributor.authorMesquita Miranda, Milene
dc.contributor.authorBhuva, Nishit
dc.contributor.authorGogarten, Jan F.
dc.contributor.authorNg, James
dc.contributor.authorThakkar, Riddhi
dc.contributor.authorSurrage Calheiros, Andrea
dc.contributor.authorMonteiro, Ana Paula Teixeira
dc.contributor.authorBozza, Fernando A.
dc.contributor.authorTschoeke, Diogo A.
dc.contributor.authorLeomil, Luciana
dc.contributor.authorde Mendonça, Marcos Cesar Lima
dc.contributor.authordos Santos Rodrigues, Cintia Damasceno
dc.contributor.authorTorres, Maria C.
dc.contributor.authorBispo de Filippis, Ana Maria
dc.contributor.authorRibeiro Nogueira, Rita Maria
dc.contributor.authorThompson, Fabiano L.
dc.contributor.authorLemos, Christina
dc.contributor.authorDurovni, Betina
dc.contributor.authorCerbino-Neto, José
dc.contributor.authorMorel, Carlos M.
dc.contributor.authorLipkin, W. Ian
dc.contributor.authorMishra, Nischay
dc.date.accessioned2019-03-21T09:38:02Z
dc.date.available2019-03-21T09:38:02Z
dc.date.issued2019-02-26none
dc.identifier.other10.1038/s41598-019-39406-9
dc.identifier.urihttp://edoc.rki.de/176904/6010
dc.description.abstractBrazil, which is hyperendemic for dengue virus (DENV), has had recent Zika (ZIKV) and (CHIKV) Chikungunya virus outbreaks. Since March 2016, CHIKV is the arbovirus infection most frequently diagnosed in Rio de Janeiro. In the analysis of 1835 syndromic patients, screened by real time RT-PCR, 56.4% of the cases were attributed to CHIKV, 29.6% to ZIKV, and 14.1% to DENV-4. Sequence analyses of CHIKV from sixteen samples revealed that the East-Central-South-African (ECSA) genotype of CHIKV has been circulating in Brazil since 2013 [95% bayesian credible interval (BCI): 03/2012-10/2013], almost a year before it was detected by arbovirus surveillance program. Brazilian cases are related to Central African Republic sequences from 1980’s. To the best of our knowledge, given the available sequence published here and elsewhere, the ECSA genotype was likely introduced to Rio de Janeiro early on 2014 (02/2014; BCI: 07/2013-08/2014) through a single event, after primary circulation in the Bahia state at the Northestern Brazil in the previous year. The observation that the ECSA genotype of CHIKV was circulating undetected underscores the need for improvements in molecular methods for viral surveillance.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectBioinformaticseng
dc.subjectViral epidemiologyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleEmergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detectionnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6010-6
dc.identifier.doihttp://dx.doi.org/10.25646/5975
dc.type.versionpublishedVersionnone
local.edoc.container-titleScientific Reportsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41598-019-39406-9#Abs1none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume9none
local.edoc.container-issue2760none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage7none
local.edoc.rki-departmentProjektgruppen/Nachwuchsgruppennone
dc.description.versionPeer Reviewednone

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