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2018-10-17Zeitschriftenartikel DOI: 10.25646/5998
What motivates Ebola survivors to donate plasma during an emergency clinical trial? The case of Ebola-Tx in Guinea
dc.contributor.authorRonse, Maya
dc.contributor.authorSaez, Almudena Mari
dc.contributor.authorGryseels, Charlotte
dc.contributor.authorBannister-Tyrrell, Melanie
dc.contributor.authorDelamou, Alexandre
dc.contributor.authorGuillard, Alain
dc.contributor.authorBriki, Mustapha
dc.contributor.authorBigey, Frédéric
dc.contributor.authorHaba, Nyankoye
dc.contributor.authorvan Griensven, Johan
dc.contributor.authorGrietens, Koen Peeters
dc.date.accessioned2019-03-22T10:50:56Z
dc.date.available2019-03-22T10:50:56Z
dc.date.issued2018-10-17none
dc.identifier.other10.1371/journal.pntd.0006885
dc.identifier.urihttp://edoc.rki.de/176904/6033
dc.description.abstractIntroduction During the 2014 Ebola Virus Disease (EVD) epidemic, the Ebola-Tx trial evaluated the use of convalescent plasma (CP) in Guinea. The effectiveness of plasmapheresis trials depends on the recruitment of plasma donors. This paper describes what motivated or deterred EVD survivors to donate CP, providing insights for future plasmapheresis trials and epidemic preparedness. Methods This qualitative study, part of Ebola-Tx, researched and addressed emergent trial difficulties through interviewing, participant observation and focus group discussions. Sampling was theoretical and retroductive analysis was done in NVivo 10. Results Willingness or hesitance to participate in plasma donation depended on factors at the interface of pre-existing social dynamics; the impact of the disease and the consequent emergency response including the trial set-up. For volunteers, motivation to donate was mainly related to the feeling of social responsibility inspired by having survived EVD and to positive perceptions of plasmapheresis technology despite still unknown trial outcomes. Conversely, confidentiality concerns when volunteering due to stigmatization of survivors and perceived decrease in vital strength and in antibodies when donating, leading to fears of loss in protection against EVD, were main deterrents. The dynamic (dis)trust in Ebola Response Actors and in other survivors further determined willingness to participate and lead to the emergence/decline of rumours related to blood stealing and treatment effectiveness. Historic inter-ethnic relations in the health care setting further defined volunteering along socio-economic and ethnic lines. Finally, lack of follow-up and of dedicated care further impacted on motivation to volunteer. Conclusions Ebola-Tx was the first trial to solicit and evaluate blood-product donation as an experimental treatment on a large scale in Sub-Saharan Africa. An effective donation system requires directly engaging with emergent social barriers and providing an effective ethical response, including improved and transparent communication, effective follow-up after donation, assuring confidentiality and determining ethical incentives.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectBlood plasmaeng
dc.subjectGuineaeng
dc.subjectEbola hemorrhagic fevereng
dc.subjectBlood transfusioneng
dc.subjectMedical educationeng
dc.subjectEbola viruseng
dc.subjectQualitative studieseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleWhat motivates Ebola survivors to donate plasma during an emergency clinical trial? The case of Ebola-Tx in Guineanone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6033-4
dc.identifier.doihttp://dx.doi.org/10.25646/5998
dc.type.versionpublishedVersionnone
local.edoc.container-titlePLOS Neglected Tropical Diseasesnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006885none
local.edoc.container-publisher-namePublic Library of Sciencenone
local.edoc.container-volume12none
local.edoc.container-issue10none
local.edoc.container-reportyear2018none
local.edoc.container-year2018none
local.edoc.container-firstpage1none
local.edoc.container-lastpage14none
dc.description.versionPeer Reviewednone

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