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2018-07-26Zeitschriftenartikel DOI: 10.25646/6002
Beyond the myths: Novel findings for old paradigms in the history of the smallpox vaccine
dc.contributor.authorEsparza, José
dc.contributor.authorNitsche, Andreas
dc.contributor.authorDamaso, Clarissa R.
dc.date.accessioned2019-03-27T09:43:50Z
dc.date.available2019-03-27T09:43:50Z
dc.date.issued2018-07-26none
dc.identifier.other10.1371/journal.ppat.1007082
dc.identifier.urihttp://edoc.rki.de/176904/6037
dc.description.abstractThe discovery of smallpox vaccination by Edward Jenner in 1796 gave a new perspective to science in the struggle against this devastating disease. Smallpox has claimed hundreds of millions of lives over the centuries. However, it was only in 1980 that the World Health Organization finally declared smallpox eradicated after an intense worldwide vaccination campaign [1]. The intriguing history of the smallpox vaccine is replete with mythology that continues to fascinate researchers today. The main mystery concerns the true origin of the vaccine matter used by Jenner and subsequent early vaccinators [2, 3]. For the 20th century, we certainly know the answer: vaccinia virus. But what of previous centuries—was cowpox or horsepox the virus used? Or was it actually vaccinia virus that was being used, and if so, how did this come about? After all, vaccinia virus has never been reported to cause natural infections in animals, except for escapee vaccine strains in Brazil and India [4]. Next-Generation Sequencing (NGS) technologies applied to genomic studies of modern and old smallpox vaccines are helping to sort out these puzzles.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleBeyond the myths: Novel findings for old paradigms in the history of the smallpox vaccinenone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6037-7
dc.identifier.doihttp://dx.doi.org/10.25646/6002
dc.type.versionpublishedVersionnone
local.edoc.container-titlePLoS Pathogensnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007082none
local.edoc.container-publisher-namePublic Library of Sciencenone
local.edoc.container-volume14none
local.edoc.container-issue7none
local.edoc.container-reportyear2018none
local.edoc.container-year2018none
local.edoc.container-firstpage1none
local.edoc.container-lastpage6none
local.edoc.rki-departmentZentrum für Biologische Gefahren und Spezielle Pathogenenone
dc.description.versionPeer Reviewednone

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