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2019-02-21Zeitschriftenartikel DOI: 10.25646/6118
No evidence of carbapenemase-producing Enterobacteriaceae in stool samples of 1,544 asylum seekers arriving in Rhineland-Palatinate, Germany, April 2016 to March, 2017
dc.contributor.authorEhlkes, Lutz
dc.contributor.authorPfeifer, Yvonne
dc.contributor.authorWerner, Guido
dc.contributor.authorIgnatius, Ralf
dc.contributor.authorVogt, Manfred
dc.contributor.authorEckmanns, Tim
dc.contributor.authorZanger, Philipp
dc.contributor.authorWalter, Jan
dc.date.accessioned2019-04-26T11:16:13Z
dc.date.available2019-04-26T11:16:13Z
dc.date.issued2019-02-21none
dc.identifier.other10.2807/1560-7917.ES.2019.24.8.1800030
dc.identifier.urihttp://edoc.rki.de/176904/6146
dc.description.abstractIntroduction: Since 2015, increased migration from Asia and Africa to Europe has raised public health concerns about potential importation of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE), specifically those producing carbapenemases (C-PE), into European hospitals. Aims: To inform infection control practices about ESBL-PE prevalence in asylum seekers and to investigate whether C-PE prevalence exceeds that in the German population. Methods: Cross-sectional study from April 2016–March 2017. Routinely collected stool samples from asylum seekers were tested for antibiotic resistant Enterobacteriaceae. Country/region of origin and demographic characteristics were explored as risk factors for faecal colonisation. Results: Of 1,544 individuals, 294 tested positive for ESBL-PE colonisation (19.0%; 95% confidence intervals (CI): 17.0–21.0). Asylum seekers originating from Afghanistan/Pakistan/Iran had a prevalence of 29.3% (95% CI: 25.6–33.2), from Syria 20.4% (95% CI: 16.1–25.2) and from Eritrea/Somalia 11.9% (95% CI: 8.7–15.7). CTX-M-15 (79%) and CTX-M-27 (10%) were the most common ESBL determinants. Highest ESBL-PE prevalences were observed in boys under 10 years and women aged 20–39 years (interaction: p = 0.03). No individuals tested positive for C-PE. Faecal C-PE colonisation prevalence in asylum seekers was not statistically significantly different from prevalence reported in German communities. Conclusion: In absence of other risk factors, being a newly arrived asylum seeker from a region with increased faecal ESBL-PE colonisation prevalence is not an indicator for C-PE colonisation and thus not a reason for pre-emptive screening and isolation upon hospital admission.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectAfghanistaneng
dc.subjectE. coli ST131eng
dc.subjectESBLeng
dc.subjectbeta-lactamase CTX-M-27eng
dc.subjectEritreaeng
dc.subjectEscherichia colieng
dc.subjectIraneng
dc.subjectPakistaneng
dc.subjectSomaliaeng
dc.subjectSyriaeng
dc.subjectbeta-lactamase CTX-M-15eng
dc.subjectcarbapenem-resistant Enterobacteriaceaeeng
dc.subjectcommunicable diseaseseng
dc.subjectcross-sectional studieseng
dc.subjectdrug resistanceeng
dc.subjectemergingeng
dc.subjectepidemiologyeng
dc.subjecthuman migrationeng
dc.subjectinfectious disease transmissioneng
dc.subjectmass screeningeng
dc.subjectmicrobialeng
dc.subjectplasmid mediated fluoroquinolone resistanceeng
dc.subjectprevalenceeng
dc.subjectrefugeeseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleNo evidence of carbapenemase-producing Enterobacteriaceae in stool samples of 1,544 asylum seekers arriving in Rhineland-Palatinate, Germany, April 2016 to March, 2017none
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6146-2
dc.identifier.doihttp://dx.doi.org/10.25646/6118
dc.type.versionpublishedVersionnone
local.edoc.container-titleEurosurveillancenone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.8.1800030#abstract_contentnone
local.edoc.container-publisher-nameInstitut de Veille Sanitairenone
local.edoc.container-volume24none
local.edoc.container-issue8none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage9none
local.edoc.rki-departmentInfektionsepidemiologienone
dc.description.versionPeer Reviewednone

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