Influenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014
dc.contributor.author | Fritsch, Annemarie | |
dc.contributor.author | Schweiger, Brunhilde | |
dc.contributor.author | Biere, Barbara | |
dc.date.accessioned | 2019-05-03T06:48:06Z | |
dc.date.available | 2019-05-03T06:48:06Z | |
dc.date.issued | 2019-03-07 | none |
dc.identifier.other | 10.2807/1560-7917.ES.2019.24.10.1800174 | |
dc.identifier.uri | http://edoc.rki.de/176904/6155 | |
dc.description.abstract | Introduction Recent data on influenza C virus indicate a possible higher clinical impact in specified patient populations than previously thought. Aim We aimed to investigate influenza C virus circulation in Germany. Methods A total of 1,588 samples from 0 to 4 year-old children presenting as outpatients with influenza-like illness (ILI) or acute respiratory infection were analysed retrospectively. The samples represented a subset of all samples from the German national surveillance system for influenza in this age group in 2012–14. The presence of influenza C virus was investigated by real-time PCR. For positive samples, information on symptoms as well as other respiratory virus co-infections was considered. Retrieved influenza C viral sequences were phylogenetically characterised. Results Influenza C viral RNA was detected in 20 (1.3% of) samples, including 16 during the 2012/13 season. The majority (18/20) of influenza C-positive patients had ILI according to the European Union definition, one patient had pneumonia. Viruses belonged to the C/Sao Paulo and C/Kanagawa lineages. Most (11/20) samples were co-infected with other respiratory viruses. Conclusion Our data are the first on influenza C virus circulation in Germany and notably from a European national surveillance system. The low detection frequency and the identified virus variants confirm earlier observations outside a surveillance system. More virus detections during the 2012/13 season indicate a variable circulation intensity in the different years studied. Influenza C virus can be considered for ILI patients. Future studies addressing its clinical impact, especially in patients with severe disease are needed. | eng |
dc.language.iso | eng | none |
dc.publisher | Robert Koch-Institut | |
dc.rights | (CC BY 3.0 DE) Namensnennung 3.0 Deutschland | ger |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/de/ | |
dc.subject | Influenza C | eng |
dc.subject | Influenza | eng |
dc.subject | influenza surveillance | eng |
dc.subject.ddc | 610 Medizin und Gesundheit | none |
dc.title | Influenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014 | none |
dc.type | article | |
dc.identifier.urn | urn:nbn:de:kobv:0257-176904/6155-2 | |
dc.identifier.doi | http://dx.doi.org/10.25646/6127 | |
dc.type.version | publishedVersion | none |
local.edoc.container-title | Eurosurveillance | none |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
local.edoc.container-url | https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.10.1800174#html_fulltext | none |
local.edoc.container-publisher-name | Institut de Veille Sanitaire | none |
local.edoc.container-volume | 24 | none |
local.edoc.container-issue | 10 | none |
local.edoc.container-reportyear | 2019 | none |
local.edoc.container-year | 2019 | none |
local.edoc.container-firstpage | 1 | none |
local.edoc.container-lastpage | 10 | none |
local.edoc.rki-department | Infektionskrankheiten | none |
dc.description.version | Peer Reviewed | none |