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2019-03-07Zeitschriftenartikel DOI: 10.25646/6127
Influenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014
dc.contributor.authorFritsch, Annemarie
dc.contributor.authorSchweiger, Brunhilde
dc.contributor.authorBiere, Barbara
dc.date.accessioned2019-05-03T06:48:06Z
dc.date.available2019-05-03T06:48:06Z
dc.date.issued2019-03-07none
dc.identifier.other10.2807/1560-7917.ES.2019.24.10.1800174
dc.identifier.urihttp://edoc.rki.de/176904/6155
dc.description.abstractIntroduction Recent data on influenza C virus indicate a possible higher clinical impact in specified patient populations than previously thought. Aim We aimed to investigate influenza C virus circulation in Germany. Methods A total of 1,588 samples from 0 to 4 year-old children presenting as outpatients with influenza-like illness (ILI) or acute respiratory infection were analysed retrospectively. The samples represented a subset of all samples from the German national surveillance system for influenza in this age group in 2012–14. The presence of influenza C virus was investigated by real-time PCR. For positive samples, information on symptoms as well as other respiratory virus co-infections was considered. Retrieved influenza C viral sequences were phylogenetically characterised. Results Influenza C viral RNA was detected in 20 (1.3% of) samples, including 16 during the 2012/13 season. The majority (18/20) of influenza C-positive patients had ILI according to the European Union definition, one patient had pneumonia. Viruses belonged to the C/Sao Paulo and C/Kanagawa lineages. Most (11/20) samples were co-infected with other respiratory viruses. Conclusion Our data are the first on influenza C virus circulation in Germany and notably from a European national surveillance system. The low detection frequency and the identified virus variants confirm earlier observations outside a surveillance system. More virus detections during the 2012/13 season indicate a variable circulation intensity in the different years studied. Influenza C virus can be considered for ILI patients. Future studies addressing its clinical impact, especially in patients with severe disease are needed.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectInfluenza Ceng
dc.subjectInfluenzaeng
dc.subjectinfluenza surveillanceeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleInfluenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014none
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6155-2
dc.identifier.doihttp://dx.doi.org/10.25646/6127
dc.type.versionpublishedVersionnone
local.edoc.container-titleEurosurveillancenone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.10.1800174#html_fulltextnone
local.edoc.container-publisher-nameInstitut de Veille Sanitairenone
local.edoc.container-volume24none
local.edoc.container-issue10none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage10none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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