Epidemiology of Tick-Borne Encephalitis (TBE) in Germany, 2001–2018
dc.contributor.author | Hellenbrand, Wiebke | |
dc.contributor.author | Kreusch, Teresa | |
dc.contributor.author | Böhmer, Merle M. | |
dc.contributor.author | Wagner-Wiening, Christiane | |
dc.contributor.author | Dobler, Gerhard | |
dc.contributor.author | Wichmann, Ole | |
dc.contributor.author | Altmann, Doris | |
dc.date.accessioned | 2019-05-03T07:50:34Z | |
dc.date.available | 2019-05-03T07:50:34Z | |
dc.date.issued | 2019-03-29 | none |
dc.identifier.other | 10.3390/pathogens8020042 | |
dc.identifier.uri | http://edoc.rki.de/176904/6159 | |
dc.description.abstract | We reviewed tick-borne encephalitis (TBE) surveillance and epidemiology in Germany, as these underlie public health recommendations, foremost vaccination. We performed descriptive analyses of notification data (2001–2018, n = 6063) according to region, demographics and clinical manifestations and calculated incidence trends using negative binomial regression. Risk areas were defined based on incidence in administrative districts. Most cases (89%) occurred in the federal states of Baden-Wurttemberg and Bavaria, where annual TBE incidence fluctuated markedly between 0.7–2.0 cases/100,000 inhabitants. A slight but significantly increasing temporal trend was observed from 2001–2018 (age-adjusted incidence rate ratio (IRR) 1.02 (95% confidence interval (CI): 1.01–1.04)), primarily driven by high case numbers in 2017–2018. Mean incidence was highest in 40–69-year-olds and in males. More males (23.7%) than females (18.0%, p = 0.02) had severe disease (encephalitis or myelitis), which increased with age, as did case-fatality (0.4% overall; 2.1% among ≥70-year-olds). Risk areas increased from 129 districts in 2007 to 161 in 2019. Expansion occurred mainly within existent southern endemic areas, with slower contiguous north-eastern and patchy north-western spread. Median vaccination coverage at school entry in risk areas in 2016–2017 ranged from 20%–41% in 4 states. Increasing TBE vaccine uptake is an urgent priority, particularly in high-incidence risk areas. | eng |
dc.language.iso | eng | none |
dc.publisher | Robert Koch-Institut | |
dc.rights | (CC BY 3.0 DE) Namensnennung 3.0 Deutschland | ger |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/de/ | |
dc.subject | Tick-borne encephalitis (TBE) | eng |
dc.subject | epidemiology | eng |
dc.subject | incidence | eng |
dc.subject | risk areas | eng |
dc.subject | clinical manifestations | eng |
dc.subject | temporospatial distribution | eng |
dc.subject | vaccination | eng |
dc.subject | Germany | eng |
dc.subject.ddc | 610 Medizin und Gesundheit | none |
dc.title | Epidemiology of Tick-Borne Encephalitis (TBE) in Germany, 2001–2018 | none |
dc.type | article | |
dc.identifier.urn | urn:nbn:de:kobv:0257-176904/6159-8 | |
dc.identifier.doi | http://dx.doi.org/10.25646/6131 | |
dc.type.version | publishedVersion | none |
local.edoc.container-title | Pathogens | none |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
local.edoc.container-url | https://www.mdpi.com/2076-0817/8/2/42 | none |
local.edoc.container-publisher-name | MDPI | none |
local.edoc.container-volume | 8 | none |
local.edoc.container-issue | 2 | none |
local.edoc.container-reportyear | 2019 | none |
local.edoc.container-year | 2019 | none |
local.edoc.container-firstpage | 1 | none |
local.edoc.container-lastpage | 16 | none |
local.edoc.rki-department | Infektionskrankheiten | none |
dc.description.version | Peer Reviewed | none |