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2009-10-15Zeitschriftenartikel DOI: 10.1161/STROKEAHA.109.559740
Low ankle-brachial index predicts cardiovascular risk after acute ischemic stroke or transient ischemic attack
dc.contributor.authorBusch, Markus
dc.contributor.authorLutz, Katrin
dc.contributor.authorRöhl, Jens-Eric
dc.contributor.authorNeuner, Bruno
dc.contributor.authorMasuhr, Florian
dc.date.accessioned2018-05-07T13:49:34Z
dc.date.available2018-05-07T13:49:34Z
dc.date.created2010-04-16
dc.date.issued2009-10-15none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rehDSwnIA0Pwg/PDF/29QuL5pUnRR1.pdf
dc.identifier.urihttp://edoc.rki.de/176904/623
dc.description.abstractBackground and purpose: A low ankle-brachial blood pressure index (ABI) is an established risk marker for cardiovascular disease and mortality in the general population, but little is known about its prognostic value in individuals with acute ischemic stroke or transient ischemic attack (TIA). Methods: An inception cohort of 204 patients with acute ischemic stroke or TIA was followed up for a mean of 2.3 years. At baseline, patients underwent ABI measurement and were assessed for risk factors, cardiovascular comorbidities, and cervical or intracranial artery stenosis. The association between low ABI and the risk of the composite outcome of stroke, myocardial infarction, or death was examined by Kaplan-Meier and Cox regression analyses. Results: A low ABI was found in 63 patients (31%) and was associated with older age, current smoking, hypertension, peripheral arterial disease, and cervical or intracranial stenosis. During a total of 453.0 person-years of follow-up, 37 patients experienced outcome events (8.2% per person-year), with a higher outcome rate per person-year in patients with low ABI (12.8% vs 6.3%, P=0.03). In survival analysis adjusted for age and stroke etiology, patients with a low ABI had a 2 times higher risk of stroke, myocardial infarction, or death than those with a normal ABI (hazard ratio=2.2; 95% CI, 1.1 to 4.5). Additional adjustment for risk factors and cardiovascular comorbidities did not attenuate the association. Conclusions: A low ABI independently predicted subsequent cardiovascular risk and mortality in patients with acute stroke or TIA. ABI measurement may help to identify high-risk patients for targeted secondary stroke prevention.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectHumanseng
dc.subject80 and overeng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectMiddle Agedeng
dc.subjectRisk Factorseng
dc.subjectCohort Studieseng
dc.subjectAgedeng
dc.subjectSmoking/epidemiologyeng
dc.subjectPredictive Value of Testseng
dc.subjectAge Factorseng
dc.subjectComorbidityeng
dc.subjectSurvival Analysiseng
dc.subjectAcute Disease/epidemiologyeng
dc.subjectAnkle Brachial Index/methodseng
dc.subjectBlood Pressure/physiologyeng
dc.subjectBrain Ischemia/mortalityeng
dc.subjectBrain Ischemia/physiopathologyeng
dc.subjectCardiovascular Diseases/mortalityeng
dc.subjectCardiovascular Diseases/physiopathologyeng
dc.subjectCarotid Stenosis/mortalityeng
dc.subjectCarotid Stenosis/physiopathologyeng
dc.subjectHypertension/mortalityeng
dc.subjectHypertension/physiopathologyeng
dc.subjectIschemic Attackeng
dc.subjectTransient/mortalityeng
dc.subjectTransient/physiopathologyeng
dc.subjectMyocardial Infarction/mortalityeng
dc.subjectMyocardial Infarction/physiopathologyeng
dc.subjectPeripheral Vascular Diseases/diagnosiseng
dc.subjectPeripheral Vascular Diseases/mortalityeng
dc.subjectPeripheral Vascular Diseases/physiopathologyeng
dc.subjectStroke/mortalityeng
dc.subjectStroke/physiopathologyeng
dc.subject.ddc610 Medizin
dc.titleLow ankle-brachial index predicts cardiovascular risk after acute ischemic stroke or transient ischemic attack
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1008322
dc.identifier.doi10.1161/STROKEAHA.109.559740
dc.identifier.doihttp://dx.doi.org/10.25646/548
local.edoc.container-titleStroke
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://stroke.ahajournals.org
local.edoc.container-publisher-nameAmerican Heart Association
local.edoc.container-volume40
local.edoc.container-issue12
local.edoc.container-year2009

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