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2019-08-01Zeitschriftenartikel DOI: 10.25646/6277
Cytomegalovirus distribution and evolution in hominines
dc.contributor.authorMurthy, Sripriya
dc.contributor.authorO’Brien, Kathryn
dc.contributor.authorAgbor, Anthony
dc.contributor.authorAngedakin, Samuel
dc.contributor.authorArandjelovic, Mimi
dc.contributor.authorAyuk Ayimisin, Emmanuel
dc.contributor.authorBailey, Emma
dc.contributor.authorBergl, Richard A.
dc.contributor.authorBrazzola, Gregory
dc.contributor.authorDieguez, Paula
dc.contributor.authorEno-Nku, Manasseh
dc.contributor.authorEshuis, Henk
dc.contributor.authorFruth, Barbara
dc.contributor.authorGillespie, Thomas R.
dc.contributor.authorGinath, Yisa
dc.contributor.authorMaryke, Gray
dc.contributor.authorHerbinger, Ilka
dc.contributor.authorJones, Sorrel
dc.contributor.authorKehoe, Laura
dc.contributor.authorKühl, Hjalmar
dc.contributor.authorKujirakwinja, Deo
dc.contributor.authorLee, Kevin
dc.contributor.authorMadinda, Nadège F.
dc.contributor.authorMitamba, Guillain
dc.contributor.authorMuhindo, Emmanuel
dc.contributor.authorNishuli, Radar
dc.contributor.authorOrmsby, Lucy J.
dc.contributor.authorPetrzelkova, Klara J.
dc.contributor.authorPlumptre, Andrew J.
dc.contributor.authorRobbins, Martha M.
dc.contributor.authorSommer, Volker
dc.contributor.authorTer Heegde, Martijn
dc.contributor.authorTodd, Angelique
dc.contributor.authorTokunda, Raymond
dc.contributor.authorWessling, Erin
dc.contributor.authorJarvis, Michael V.
dc.contributor.authorLeendertz, Fabian H.
dc.contributor.authorEhlers, Bernhard
dc.contributor.authorCalvignac-Spencer, Sébastien
dc.date.accessioned2019-09-18T09:46:39Z
dc.date.available2019-09-18T09:46:39Z
dc.date.issued2019-08-01none
dc.identifier.other10.1093/ve/vez015
dc.identifier.urihttp://edoc.rki.de/176904/6292
dc.description.abstractHerpesviruses are thought to have evolved in very close association with their hosts. This is notably the case for cytomegaloviruses (CMVs; genus Cytomegalovirus) infecting primates, which exhibit a strong signal of co-divergence with their hosts. Some herpesviruses are however known to have crossed species barriers. Based on a limited sampling of CMV diversity in the hominine (African great ape and human) lineage, we hypothesized that chimpanzees and gorillas might have mutually exchanged CMVs in the past. Here, we performed a comprehensive molecular screening of all 9 African great ape species/subspecies, using 675 fecal samples collected from wild animals. We identified CMVs in eight species/subspecies, notably generating the first CMV sequences from bonobos. We used this extended dataset to test competing hypotheses with various degrees of co-divergence/number of host switches while simultaneously estimating the dates of these events in a Bayesian framework. The model best supported by the data involved the transmission of a gorilla CMV to the panine (chimpanzee and bonobo) lineage and the transmission of a panine CMV to the gorilla lineage prior to the divergence of chimpanzees and bonobos, more than 800,000 years ago. Panine CMVs then co-diverged with their hosts. These results add to a growing body of evidence suggesting that viruses with a double-stranded DNA genome (including other herpesviruses, adenoviruses, and papillomaviruses) often jumped between hominine lineages over the last few million years.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectcytomegaloviruseng
dc.subjecthominineeng
dc.subjecthost switcheng
dc.subjectcodivergenceeng
dc.subjectdsDNA viruseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleCytomegalovirus distribution and evolution in homininesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6292-7
dc.identifier.doihttp://dx.doi.org/10.25646/6277
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirus Evolutionnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://academic.oup.com/ve/article/5/2/vez015/5542563none
local.edoc.container-publisher-nameOxford University Pressnone
local.edoc.container-volume5none
local.edoc.container-issue2none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage11none
local.edoc.rki-departmentProjektgruppen/Nachwuchsgruppennone
dc.description.versionPeer Reviewednone

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