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2019-09-04Zeitschriftenartikel DOI: 10.25646/6404
Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study
dc.contributor.authorBellikci-Koyu, Ezgi
dc.contributor.authorSarer-Yurekli, Banu Pınar
dc.contributor.authorAkyon, Yakut
dc.contributor.authorAydin-Kose, Fadime
dc.contributor.authorKaragozlu, Cem
dc.contributor.authorOzgen, Ahmet Gokhan
dc.contributor.authorBrinkmann, Annika
dc.contributor.authorNitsche, Andreas
dc.contributor.authorErgunay, Koray
dc.contributor.authorYilmaz, Engin
dc.contributor.authorBuyuktuncer, Zehra
dc.date.accessioned2019-11-07T07:40:22Z
dc.date.available2019-11-07T07:40:22Z
dc.date.issued2019-09-04none
dc.identifier.other10.3390/nu11092089
dc.identifier.urihttp://edoc.rki.de/176904/6418
dc.description.abstractSeveral health-promoting effects of kefir have been suggested, however, there is limited evidence for its potential effect on gut microbiota in metabolic syndrome This study aimed to investigate the effects of regular kefir consumption on gut microbiota composition, and their relation with the components of metabolic syndrome. In a parallel-group, randomized, controlled clinical trial setting, patients with metabolic syndrome were randomized to receive 180 mL/day kefir (n = 12) or unfermented milk (n = 10) for 12 weeks. Anthropometrical measurements, blood samples, blood pressure measurements, and fecal samples were taken at the beginning and end of the study. Fasting insulin, HOMA-IR, TNF-α, IFN-γ, and systolic and diastolic blood pressure showed a significant decrease by the intervention of kefir (p ≤ 0.05, for each). However, no significant difference was obtained between the kefir and unfermented milk groups (p > 0.05 for each). Gut microbiota analysis showed that regular kefir consumption resulted in a significant increase only in the relative abundance of Actinobacteria (p = 0.023). No significant change in the relative abundance of Bacteroidetes, Proteobacteria or Verrucomicrobia by kefir consumption was obtained. Furthermore, the changes in the relative abundance of sub-phylum bacterial populations did not differ significantly between the groups (p > 0.05, for each). Kefir supplementation had favorable effects on some of the metabolic syndrome parameters, however, further investigation is needed to understand its effect on gut microbiota composition.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectkefireng
dc.subjectgut microbiotaeng
dc.subjectmetabolic syndromeeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleEffects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Studynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6418-3
dc.identifier.doihttp://dx.doi.org/10.25646/6404
dc.type.versionpublishedVersionnone
local.edoc.container-titleNutrientsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/2072-6643/11/9/2089#abstractcnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume11none
local.edoc.container-issue9none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage23none
local.edoc.rki-departmentZentrum für Biologische Gefahren und Spezielle Pathogenenone
dc.description.versionPeer Reviewednone

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