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2019-11-13Zeitschriftenartikel DOI: 10.25646/6412
The gut microbiome of horses: current research on equine enteral microbiota and future perspectives
dc.contributor.authorKauter, Anne
dc.contributor.authorEpping, Lennard
dc.contributor.authorSemmler, Torsten
dc.contributor.authorAntao, Esther-Maria
dc.contributor.authorKannapin, Dania
dc.contributor.authorStoeckle, Sabita D.
dc.contributor.authorGehlen, Heidrun
dc.contributor.authorLübke-Becker, Antina
dc.contributor.authorGünther, Sebastian
dc.contributor.authorWieler, Lothar H.
dc.contributor.authorWalther, Birgit
dc.date.accessioned2019-11-14T13:36:54Z
dc.date.available2019-11-14T13:36:54Z
dc.date.issued2019-11-13none
dc.identifier.other10.1186/s42523-019-0013-3
dc.identifier.urihttp://edoc.rki.de/176904/6426
dc.description.abstractUnderstanding the complex interactions of microbial communities including bacteria, archaea, parasites, viruses and fungi of the gastrointestinal tract (GIT) associated with states of either health or disease is still an expanding research field in both, human and veterinary medicine. GIT disorders and their consequences are among the most important diseases of domesticated Equidae, but current gaps of knowledge hinder adequate progress with respect to disease prevention and microbiome-based interventions. Current literature on enteral microbiomes mirrors a vast data and knowledge imbalance, with only few studies tackling archaea, viruses and eukaryotes compared with those addressing the bacterial components. Until recently, culture-dependent methods were used for the identification and description of compositional changes of enteral microorganisms, limiting the outcome to cultivatable bacteria only. Today, next generation sequencing technologies provide access to the entirety of genes (microbiome) associated with the microorganisms of the equine GIT including the mass of uncultured microbiota, or “microbial dark matter”. This review illustrates methods commonly used for enteral microbiome analysis in horses and summarizes key findings reached for bacteria, viruses and fungi so far. Moreover, reasonable possibilities to combine different explorative techniques are described. As a future perspective, knowledge expansion concerning beneficial compositions of microorganisms within the equine GIT creates novel possibilities for early disorder diagnostics as well as innovative therapeutic approaches. In addition, analysis of shotgun metagenomic data enables tracking of certain microorganisms beyond species barriers: transmission events of bacteria including pathogens and opportunists harboring antibiotic resistance factors between different horses but also between humans and horses will reach new levels of depth concerning strain-level distinctions.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectHorseeng
dc.subjectMicrobiomeeng
dc.subjectGastrointestinal tracteng
dc.subjectMicrobiotaeng
dc.subjectDiseaseeng
dc.subjectHealtheng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleThe gut microbiome of horses: current research on equine enteral microbiota and future perspectivesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6426-7
dc.identifier.doihttp://dx.doi.org/10.25646/6412
dc.type.versionpublishedVersionnone
local.edoc.container-titleAnimal Microbiomenone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://animalmicrobiome.biomedcentral.com/articles/10.1186/s42523-019-0013-3none
local.edoc.container-publisher-nameBioMedCentralnone
local.edoc.container-volume1none
local.edoc.container-issue2019none
local.edoc.container-reportyear14none
local.edoc.container-firstpage1none
local.edoc.container-lastpage15none
dc.description.versionPeer Reviewednone

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