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2019-05-23Zeitschriftenartikel DOI: 10.25646/6615
Toxoplasmosis in Germany: Epidemiology, Diagnosis, Risk Factors, and Treatment
dc.contributor.authorPleyer, Uwe
dc.contributor.authorGroß, Uwe
dc.contributor.authorSchlüter, Dirk
dc.contributor.authorWilking, Hendrik
dc.contributor.authorSeeber, Frank
dc.date.accessioned2020-03-27T11:33:04Z
dc.date.available2020-03-27T11:33:04Z
dc.date.issued2019-05-23none
dc.identifier.other10.3238/arztebl.2019.0435
dc.identifier.urihttp://edoc.rki.de/176904/6574
dc.description.abstractBackground: With approximately 30% of the world population infected, Toxoplasma gondii is one of the most widespread pathogenic parasites in both humans and animals and a major problem for health economics in many countries. Methods: This review is based on the findings of individual studies, meta-analyses, and Cochrane Reviews retrieved by a selective literature survey of the Medline and Google Scholar databases. Results: Current data indicate a high rate of Toxoplasma gondii infection in Germany, ranging from 20% to 77% depending on age (95% confidence interval for 18- to 29-year-olds [17.0; 23.1]; for 70- to 79-year-olds [72.7; 80.5]). Male sex, caring for a cat, and a body mass index of 30 or more are independent risk factors for seroconversion. Postnatally acquired (food-related) infection is predominant, but maternal-to-fetal transmission still plays an important role. While most infections are asymptomatic, congenital toxoplasmosis and reactivated Toxoplasma encephalitis in immunosuppressed persons (transplant recipients and others) are sources of considerable morbidity. Toxoplasma gondii infection of the retina is the most common cause of infectious uveitis in Germany. The diagnosis and treatment of this type of parasitic infection are particular to the specific organs involved in the individual patient. Conclusion: Desirable steps for the near future include development of an effective treatment for the cystic stage and identification of biomarkers to assess the risk of reactivation and predict the disease course.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleToxoplasmosis in Germany: Epidemiology, Diagnosis, Risk Factors, and Treatmentnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6574-9
dc.identifier.doihttp://dx.doi.org/10.25646/6615
dc.type.versionpublishedVersionnone
local.edoc.container-titleDeutsches Ärzteblatt Internationalnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.aerzteblatt.de/int/archive/article?id=208358none
local.edoc.container-publisher-nameDeutscher Ärzte-Verlagnone
local.edoc.container-volume2019none
local.edoc.container-issue116none
local.edoc.container-year2019none
local.edoc.container-firstpage435none
local.edoc.container-lastpage444none
local.edoc.rki-departmentInfektionsepidemiologienone
dc.description.versionPeer Reviewednone

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