Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line
| dc.contributor.author | Abdulsalam, Ibrahim | |
| dc.contributor.author | Rasheed, Kashif | |
| dc.contributor.author | Sveinbjørnsson, Baldur | |
| dc.contributor.author | Ehlers, Bernhard | |
| dc.contributor.author | Moens, Ugo | |
| dc.date.accessioned | 2020-07-03T10:06:22Z | |
| dc.date.available | 2020-07-03T10:06:22Z | |
| dc.date.issued | 2020-04-19 | none |
| dc.identifier.other | 10.1186/s12985-020-01317-x | |
| dc.identifier.uri | http://edoc.rki.de/176904/6869 | |
| dc.description.abstract | Merkel cell polyomavirus (MCPyV) is a human polyomavirus that establishes a life-long harmless infection in most individuals, with dermal fibroblasts believed to be the natural host cell. However, this virus is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. Several MCPyV variants with polymorphism in their promoter region have been isolated, but it is not known whether these differences affect the biological properties of the virus. | eng |
| dc.language.iso | eng | none |
| dc.publisher | Robert Koch-Institut | |
| dc.subject | Non-coding control region | eng |
| dc.subject | Large T-antigen | eng |
| dc.subject | Luciferase assay | eng |
| dc.subject | MCC13 cells | eng |
| dc.subject | MCPyV | eng |
| dc.subject | Mutations | eng |
| dc.subject.ddc | 610 Medizin und Gesundheit | none |
| dc.title | Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line | none |
| dc.type | article | |
| dc.identifier.urn | urn:nbn:de:kobv:0257-176904/6869-2 | |
| dc.identifier.doi | http://dx.doi.org/10.25646/6987 | |
| dc.type.version | publishedVersion | none |
| local.edoc.container-title | Virology Journal | none |
| local.edoc.type-name | Zeitschriftenartikel | |
| local.edoc.container-type | periodical | |
| local.edoc.container-type-name | Zeitschrift | |
| local.edoc.container-url | https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01317-x | none |
| local.edoc.container-publisher-name | BMC | none |
| local.edoc.container-volume | 54 | none |
| local.edoc.container-issue | 17 | none |
| local.edoc.container-reportyear | 2020 | none |
| local.edoc.rki-department | Infektionskrankheiten | none |
| dc.description.version | Peer Reviewed | none |