Das System wird zu Wartungszwecken am 28.10. um 9 Uhr heruntergefahren. Server maintenance October the 28th at 9 o'clock.

Show simple item record

2020-05-26Zeitschriftenartikel DOI: 10.25646/7103
Severe Multiorgan Failure Following Yellow Fever Vaccination
dc.contributor.authorDomingo, Cristina
dc.contributor.authorLamerz, Judith
dc.contributor.authorCadar, Daniel
dc.contributor.authorStojkovic, Marija
dc.contributor.authorEisermann, Philip
dc.contributor.authorMerle, Uta
dc.contributor.authorNitsche, Andreas
dc.contributor.authorSchnitzler, Paul
dc.date.accessioned2020-08-21T09:33:35Z
dc.date.available2020-08-21T09:33:35Z
dc.date.issued2020-05-26none
dc.identifier.otherdoi.org/10.3390/vaccines8020249
dc.identifier.urihttp://edoc.rki.de/176904/6943
dc.description.abstractBackground: The yellow fever (YF) vaccination is recommended by the WHO for peopletraveling or living in endemic areas at risk for yellow fever infections in Africa and South America.Although the live attenuated yellow fever vaccine is a safe and efficient vaccine, rare serious adverseevents after vaccination have been reported. Case presentation: We present the case of a 74-year-oldmale with multiorgan failure after yellow fever vaccination for a trip to Brazil. The patient requiredadmission to the intensive care unit with a prolonged stay due to severe organ dysfunction. Five daysafter the YF vaccination, the patient experienced nausea, vomiting, diarrhea, and general illness. Threedays later he sought medical attention and was transferred to the University Hospital Heidelberg withbeginning multiorgan failure and severe septic shock, including hypotonia, tachypnea, thrombopenia,and acute renal failure the same day. Within one week after vaccination, antibodies against YF viruswere already detectable and progressively increased over the next two weeks. Viral RNA was detectedin serum on the day of admission, with a viral load of 1.0×105copies/mL. The YF virus (YFV) RNAwas also present in tracheal secretions for several weeks and could be detected in urine samples upto 20 weeks after vaccination, with a peak viral load of 1.3×106copies/mL. After 20 weeks in theICU with nine weeks of mechanical ventilation, the patient was transferred to another hospital forfurther recovery. Conclusions: The risk for severe adverse events due to the YF vaccination should bebalanced against the risk of acquiring a severe YF infection, especially in elderly travelerseng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectyellow fever viruseng
dc.subjectvaccinationeng
dc.subjectviscerotropic diseaseeng
dc.subjectmultiorgan failureeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSevere Multiorgan Failure Following Yellow Fever Vaccinationnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6943-4
dc.identifier.doihttp://dx.doi.org/10.25646/7103
dc.type.versionpublishedVersionnone
local.edoc.container-titleVaccinesnone
local.edoc.pages7none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/2076-393X/8/2/249none
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume8none
local.edoc.container-issue2none
local.edoc.container-reportyear2020none
local.edoc.rki-departmentZentrum für Biologische Gefahren und Spezielle Pathogenenone
dc.description.versionPeer Reviewednone

Show simple item record