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2021-01-08Zeitschriftenartikel DOI: 10.25646/7892
Hypervirulent Klebsiella pneumoniae of Lineage ST66-K2 Caused Tonsillopharyngitis in a German Patient
dc.contributor.authorKlaper, Kathleen
dc.contributor.authorWendt, Sebastian
dc.contributor.authorLübbert, Christoph
dc.contributor.authorLippmann, Norman
dc.contributor.authorPfeifer, Yvonne
dc.contributor.authorWerner, Guido
dc.date.accessioned2021-01-23T09:59:50Z
dc.date.available2021-01-23T09:59:50Z
dc.date.issued2021-01-08none
dc.identifier.other10.3390/microorganisms9010133
dc.identifier.urihttp://edoc.rki.de/176904/7681
dc.description.abstractHypervirulent Klebsiella pneumoniae (hvKp) is a novel pathotype that has been rarely described in Europe. This study characterizes a hvKp isolate that caused a community-acquired infection. The hypermucoviscous Klebsiella pneumoniae (K. pneumoniae) strain 18-0005 was obtained from a German patient with tonsillopharyngitis in 2017. Antibiotic susceptibility testing was performed and the genome was sequenced by Illumina and Nanopore technology. Whole genome data were analyzed by conducting core genome multilocus sequence typing (cgMLST) and single nucleotide polymorphism (SNP) analysis. Virulence genes were predicted by applying Kleborate. Phenotypic and whole genome analyses revealed a high similarity of the study isolate 18-0005 to the recently reported antibiotic-susceptible hvKp isolate SB5881 from France and the “ancestral” strain Kp52.145; both were assigned to the ST66-K2 lineage. Comparative genomic analysis of the three plasmids showed that the 18-0005 plasmid II differs from SB5881 plasmid II by an additional 3 kb integrated fragment of plasmid I. Our findings demonstrate the genetic flexibility of hvKp and the occurrence of a strain of the clonal group CG66-K2 in Germany. Hence, it emphasizes the need to improve clinical awareness and infection monitoring of hvKp.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectKlebsiella pneumoniaeeng
dc.subjectcommunity-acquired infectioneng
dc.subjectvirulenceeng
dc.subjectplasmidseng
dc.subjectGermanyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleHypervirulent Klebsiella pneumoniae of Lineage ST66-K2 Caused Tonsillopharyngitis in a German Patientnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/7681-9
dc.identifier.doihttp://dx.doi.org/10.25646/7892
dc.type.versionpublishedVersionnone
local.edoc.container-titlemicroorganismsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/2076-2607/9/1/133none
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume9none
local.edoc.container-issue1none
local.edoc.container-reportyear2021none
local.edoc.container-firstpage1none
local.edoc.container-lastpage6none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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