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2021-01-25Zeitschriftenartikel DOI: 10.1016/j.cub.2020.10.015
Asymptomatic Infection of Marburg Virus Reservoir Bats Is Explained by a Strategy of Immunoprotective Disease Tolerance
dc.contributor.authorGuito, Jonathan C.
dc.contributor.authorPrescott, Joseph B.
dc.contributor.authorArnold, Catherine E.
dc.contributor.authorAmman, Brian R.
dc.contributor.authorSchuh, Amy J.
dc.contributor.authorSpengler, Jessica R.
dc.contributor.authorSealy, Tara K.
dc.contributor.authorHarmon, Jessica R.
dc.contributor.authorColeman-McCray, JoAnn D.
dc.contributor.authorKulcsar, Kirsten A.
dc.contributor.authorNagle, Elyse R.
dc.contributor.authorKumar, Raina
dc.contributor.authorPalacios, Gustavo
dc.contributor.authorSanchez-Lockhart, Mariano
dc.contributor.authorTowner, Jonathan S.
dc.date.accessioned2021-02-03T16:58:53Z
dc.date.available2021-02-03T16:58:53Z
dc.date.issued2021-01-25none
dc.identifier.other10.1016/j.cub.2020.10.015
dc.identifier.urihttp://edoc.rki.de/176904/7742
dc.description.abstractMarburg virus (MARV) is among the most virulent pathogens of primates, including humans. Contributors to severe MARV disease include immune response suppression and inflammatory gene dysregulation (“cytokine storm”), leading to systemic damage and often death. Conversely, MARV causes little to no clinical disease in its reservoir host, the Egyptian rousette bat (ERB). Previous genomic and in vitro data suggest that a tolerant ERB immune response may underlie MARV avirulence, but no significant examination of this response in vivo yet exists. Here, using colony-bred ERBs inoculated with a bat isolate of MARV, we use species-specific antibodies and an immune gene probe array (NanoString) to temporally characterize the transcriptional host response at sites of MARV replication relevant to primate pathogenesis and immunity, including CD14+ monocytes/macrophages, critical immune response mediators, primary MARV targets, and skin at the inoculation site, where highest viral loads and initial engagement of antiviral defenses are expected. Our analysis shows that ERBs upregulate canonical antiviral genes typical of mammalian systems, such as ISG15, IFIT1, and OAS3, yet demonstrate a remarkable lack of significant induction of proinflammatory genes classically implicated in primate filoviral pathogenesis, including CCL8, FAS, and IL6. Together, these findings offer the first in vivo functional evidence for disease tolerance as an immunological mechanism by which the bat reservoir asymptomatically hosts MARV. More broadly, these data highlight factors determining disparate outcomes between reservoir and spillover hosts and defensive strategies likely utilized by bat hosts of other emerging pathogens, knowledge that may guide development of effective antiviral therapies.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectfiloviruseng
dc.subjectMarburg viruseng
dc.subjectbateng
dc.subjectreservoir hosteng
dc.subjectemerging zoonotic pathogeneng
dc.subjectimmune responseeng
dc.subjectdisease toleranceeng
dc.subjectvirus-host interactioneng
dc.subjectgene expressioneng
dc.subjectmonocyteeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleAsymptomatic Infection of Marburg Virus Reservoir Bats Is Explained by a Strategy of Immunoprotective Disease Tolerancenone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/7742-8
dc.identifier.doihttps://doi.org/10.1016/j.cub.2020.10.015
dc.identifier.doihttp://dx.doi.org/10.25646/7965
dc.type.versionpublishedVersionnone
local.edoc.container-titleCurrent Biologynone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/journal/current-biology/vol/31/issue/2none
local.edoc.container-publisher-nameCell Press
local.edoc.container-volume31none
local.edoc.container-issue2none
local.edoc.container-reportyear2021none
local.edoc.container-firstpage1none
local.edoc.container-lastpage20none
local.edoc.rki-departmentZentrum für Biologische Gefahren und Spezielle Pathogenenone
dc.description.versionPeer Reviewednone

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