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2020-05-30Zeitschriftenartikel DOI: 10.1016/j.mmcr.2020.05.007
Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response
Wilmes, Dunja
Schui, Daniela
Held, Jürgen
Ackermann, Sina
Geipel, Udo
Emrich, Kai
Winkelmann, Ernst-Joachim
Rickerts, Volker
We describe a patient with a disseminated coccidioidomycosis. Biomarkers in serum during itraconazole therapy showed a rapid clearing of Coccidioides DNA as detected by PCR. Coccidioides antibody detection by lateral flow assay became negative after one year and decreased from 1:64 to 1:8 in the complement fixation test after two years. The (1 → 3)-ß-D-glucan levels normalised after two years without increase after cessation of antifungal therapy. Biomarkers in serum may guide treatment decisions in disseminated coccidioidomycosis.
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(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschland(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschland(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschland(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschland
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DOI
10.1016/j.mmcr.2020.05.007
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https://doi.org/10.1016/j.mmcr.2020.05.007
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<a href="https://doi.org/10.1016/j.mmcr.2020.05.007">https://doi.org/10.1016/j.mmcr.2020.05.007</a>