Evaluation of poliovirus antibody titers in orally vaccinated semi-captive chimpanzees in Uganda
dc.contributor.author | Mugisha, Lawrence | |
dc.contributor.author | Pauli, Georg | |
dc.contributor.author | Opuda-Asibo, John | |
dc.contributor.author | Joseph, Olobo O. | |
dc.contributor.author | Leendertz, Fabian | |
dc.contributor.author | Diedrich, Sabine | |
dc.date.accessioned | 2018-05-07T14:28:17Z | |
dc.date.available | 2018-05-07T14:28:17Z | |
dc.date.created | 2011-03-10 | |
dc.date.issued | 2010-01-25 | none |
dc.identifier.other | http://edoc.rki.de/oa/articles/re3LAb6fqMTYA/PDF/27f9cYI1m2Ews.pdf | |
dc.identifier.uri | http://edoc.rki.de/176904/831 | |
dc.description.abstract | Background: To understand immunological responses in chimpanzees vaccinated with live-attenuated vaccine (oral polio vaccine; OPV), serum neutralizing antibodies against poliovirus types 1, 2, and 3 were investigated over time. Methods: The neutralizing antibody titers against poliovirus types 1, 2, and 3 were determined by microneutralization test using 100 ID50 of poliovirus types 1, 2, and 3 (Sabin strains). Results: Neutralizing antibodies against poliovirus types 1, 2, and 3 were detected in 85.7%, 71.4%, and 65% of the serum from 42 chimpanzees tested 9 years post-vaccination. The neutralizing antibody titers in chimpanzees were similar to the documented levels in human studies as an indicator of vaccine efficacy. Conclusions: This study reveals persistence of neutralizing antibodies in chimpanzees for at least 9 years after vaccination with OPV. This first study in chimpanzees provides useful information for the evaluation of the success of vaccination with OPV in other captive apes. | eng |
dc.language.iso | eng | |
dc.publisher | Robert Koch-Institut, Infektionskrankheiten / Erreger | |
dc.subject | chimpanzees | eng |
dc.subject | great apes | eng |
dc.subject | neutralizing antibodies | eng |
dc.subject | poliomyelitis | eng |
dc.subject | transmission | eng |
dc.subject.ddc | 610 Medizin | |
dc.title | Evaluation of poliovirus antibody titers in orally vaccinated semi-captive chimpanzees in Uganda | |
dc.type | periodicalPart | |
dc.identifier.urn | urn:nbn:de:0257-10012797 | |
dc.identifier.doi | 10.1111/j.1600-0684.2010.00400.x | |
dc.identifier.doi | http://dx.doi.org/10.25646/756 | |
local.edoc.container-title | Journal of Medical Primatology | |
local.edoc.container-text | Mugisha, L., Pauli, G., Opuda-Asibo, J., Joseph, O., Leendertz, F. and Diedrich, S. (2010) Evaluation of poliovirus antibody titers in orally vaccinated semi-captive chimpanzees in Uganda. Journal of Medical Primatology, 39: 123–128. | |
local.edoc.fp-subtype | Artikel | |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
local.edoc.container-url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0684.2010.00400.x/abstract | |
local.edoc.container-publisher-name | Wiley | |
local.edoc.container-volume | 39 | |
local.edoc.container-issue | 2 | |
local.edoc.container-year | 2010 |