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2011-03-08Zeitschriftenartikel DOI: 10.1371/journal.pone.0017781
Trouble with Bleeding: Risk Factors for Acute Hepatitis C among HIV-Positive Gay Men from Germany—A Case-Control Study
dc.contributor.authorSchmidt, Axel J.
dc.contributor.authorRockstroh, Jürgen
dc.contributor.authorVogel, Martin
dc.contributor.authorHeiden, Matthias an der
dc.contributor.authorBaillot, Armin
dc.contributor.authorKrznaric, Ivanka
dc.contributor.authorRadun, Doris
dc.date.accessioned2018-05-07T14:30:41Z
dc.date.available2018-05-07T14:30:41Z
dc.date.created2011-03-28
dc.date.issued2011-03-08none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rec3Bq2yOa5X2/PDF/24AGwdYeiHBpo.pdf
dc.identifier.urihttp://edoc.rki.de/176904/844
dc.description.abstractObjectives: To identify risk factors for hepatitis C among HIV-positive men who have sex with men (MSM), focusing on potential sexual, nosocomial, and other non-sexual determinants. Background: Outbreaks of hepatitis C virus (HCV) infections among HIV-positive MSM have been reported by clinicians in post-industrialized countries since 2000. The sexual acquisition of HCV by gay men who are HIV positive is not, however, fully understood. Methods: Between 2006 and 2008, a case-control study was embedded into a behavioural survey of MSM in Germany. Cases were HIV-positive and acutely HCV-co-infected, with no history of injection drug use. HIV-positive MSM without known HCV infection, matched for age group, served as controls. The HCV-serostatus of controls was assessed by serological testing of dried blood specimens. Univariable and multivariable regression analyses were used to identify factors independently associated with HCV-co-infection. Results: 34 cases and 67 controls were included. Sex-associated rectal bleeding, receptive fisting and snorting cocaine/ amphetamines, combined with group sex, were independently associated with case status. Among cases, surgical interventions overlapped with sex-associated rectal bleeding. Conclusions: Sexual practices leading to rectal bleeding, and snorting drugs in settings of increased HCV-prevalence are risk factors for acute hepatitis C. We suggest that sharing snorting equipment as well as sharing sexual partners might be modes of sexual transmission. Condoms and gloves may not provide adequate protection if they are contaminated with blood. Public health interventions for HIV-positive gay men should address the role of blood in sexual risk behaviour. Further research is needed into the interplay of proctosurgery and sex-associated rectal bleeding.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectHumanseng
dc.subjectGermany/epidemiologyeng
dc.subjectMaleeng
dc.subjectMiddle Agedeng
dc.subjectRisk Factorseng
dc.subjectAdulteng
dc.subjectCase-Control Studieseng
dc.subjectAgedeng
dc.subjectLogistic Modelseng
dc.subjectMultivariate Analysiseng
dc.subjectYoung Adulteng
dc.subjectHepatitis C/epidemiologyeng
dc.subjectAcute Diseaseeng
dc.subjectCondomseng
dc.subjectCross Infection/complicationseng
dc.subjectDemographyeng
dc.subjectHIV Seropositivity/complicationseng
dc.subjectHealth Knowledge Attitudes Practiceeng
dc.subjectHemorrhage/complicationseng
dc.subjectHepatitis C/complicationseng
dc.subjectHomosexuality Male/statistics & numerical dataeng
dc.subject.ddc610 Medizin
dc.titleTrouble with Bleeding: Risk Factors for Acute Hepatitis C among HIV-Positive Gay Men from Germany—A Case-Control Study
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10013077
dc.identifier.doi10.1371/journal.pone.0017781
dc.identifier.doihttp://dx.doi.org/10.25646/769
local.edoc.container-titlePLoS One
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017781
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume6
local.edoc.container-issue3
local.edoc.container-year2011

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