Logo of Robert Koch InstituteLogo of Robert Koch Institute
Publication Server of Robert Koch Instituteedoc
de|en
View Item 
  • edoc-Server Home
  • Artikel in Fachzeitschriften
  • Artikel in Fachzeitschriften
  • View Item
  • edoc-Server Home
  • Artikel in Fachzeitschriften
  • Artikel in Fachzeitschriften
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.
All of edoc-ServerCommunity & CollectionTitleAuthorSubjectThis CollectionTitleAuthorSubject
PublishLoginRegisterHelp
StatisticsView Usage Statistics
All of edoc-ServerCommunity & CollectionTitleAuthorSubjectThis CollectionTitleAuthorSubject
PublishLoginRegisterHelp
StatisticsView Usage Statistics
View Item 
  • edoc-Server Home
  • Artikel in Fachzeitschriften
  • Artikel in Fachzeitschriften
  • View Item
  • edoc-Server Home
  • Artikel in Fachzeitschriften
  • Artikel in Fachzeitschriften
  • View Item
2020-12-09Zeitschriftenartikel DOI: 10.25646/8880
Variable Sensitivity of SARS-CoV-2 Molecular Detection in European Expert Laboratories: External Quality Assessment, June and July 2020
Fischer, Carlo
Mögling, Ramona
Melidou, Angeliki
Kühne, Arne
Oliveira-Filho, Edmilson F.
Wolff, Thorsten
Reiche, Janine
Broberg, Eeva
Drosten, Christian
Meijer, Adam
Leitmeyer, Katrin
Drexler, Jan Felix
Reusken, Chantal B.E.M.
During the ongoing coronavirus disease 2019 (COVID-19) outbreak, robust detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key element for clinical management and to interrupt transmission chains. We organized an external quality assessment (EQA) of molecular detection of SARS-CoV-2 for European expert laboratories. An EQA panel composed of 12 samples, containing either SARS-CoV-2 at different concentrations to evaluate sensitivity or other respiratory viruses to evaluate specificity of SARS-CoV-2 testing, was distributed to 68 laboratories in 35 countries. Specificity samples included seasonal human coronaviruses hCoV-229E, hCoV-NL63, and hCoV-OC43, as well as Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and human influenza viruses A and B. Sensitivity results differed among laboratories, particularly for low-concentration SARS-CoV-2 samples. Results indicated that performance was mostly independent of the selection of specific extraction or PCR methods.
Files in this item
Thumbnail
Variable Sensitivity of SARS-CoV-2 Molecular Detection in European Expert Laboratories- External Quality Assessment, June and July 2020.pdf — Adobe PDF — 1.070 Mb
MD5: f6c4342e51d2db1e71bd4457b0a6c67c
Cite
BibTeX
EndNote
RIS
(CC BY 3.0 DE) Namensnennung 3.0 Deutschland(CC BY 3.0 DE) Namensnennung 3.0 Deutschland
Details
Terms of Use Imprint Policy Data Privacy Statement Contact

The Robert Koch Institute is a Federal Institute

within the portfolio of the Federal Ministry of Health

© Robert Koch Institute

All rights reserved unless explicitly granted.

 
DOI
10.25646/8880
Permanent URL
http://dx.doi.org/10.25646/8880
HTML
<a href="http://dx.doi.org/10.25646/8880">http://dx.doi.org/10.25646/8880</a>