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2011-03-25Zeitschriftenartikel DOI: 10.1186/1743-422X-8-139
Rapid detection of anti-Vaccinia virus neutralizing antibodies
dc.contributor.authorKramski, Marit
dc.contributor.authorDrozd, Anna
dc.contributor.authorLichtfuss, Gregor F.
dc.contributor.authorDabrowski, Piotr Wojtek
dc.contributor.authorEllerbrok, Heinz
dc.date.accessioned2018-05-07T14:33:25Z
dc.date.available2018-05-07T14:33:25Z
dc.date.created2011-04-13
dc.date.issued2011-03-25none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reoLlZ41n0aU/PDF/23RWLAEJl4vSQ.pdf
dc.identifier.urihttp://edoc.rki.de/176904/859
dc.description.abstractIncreasing infections with Monkeypox and Cowpox viruses pose a continuous and growing threat to human health. The standard method for detecting poxvirus neutralizing antibodies is the plaque-reduction neutralization test that is specific but also time-consuming and laborious. Therefore, a rapid and reliable method was developed to determine neutralizing antibody titers within twelve hours. The new assay measures viral mRNA transcription as a marker for actively replicating virus after incomplete neutralization using real-time PCR.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Biologische Sicherheit
dc.subjectCell Lineeng
dc.subjectHumanseng
dc.subjectVirus Replicationeng
dc.subjectPolymerase Chain Reaction/methodseng
dc.subjectVaccinia virus/isolation & purificationeng
dc.subjectNeutralization Testseng
dc.subjectVaccinia virus/geneticseng
dc.subjectAntibodies Viral/immunologyeng
dc.subjectAntibodies Neutralizing/analysiseng
dc.subjectAntibodies Neutralizing/immunologyeng
dc.subjectAntibodies Viral/analysiseng
dc.subjectVaccinia/diagnosiseng
dc.subjectVaccinia/immunologyeng
dc.subjectVaccinia virus/immunologyeng
dc.subjectVaccinia virus/physiologyeng
dc.subject.ddc610 Medizin
dc.titleRapid detection of anti-Vaccinia virus neutralizing antibodies
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10013975
dc.identifier.doi10.1186/1743-422X-8-139
dc.identifier.doihttp://dx.doi.org/10.25646/784
local.edoc.container-titleVirology Journal
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.virologyj.com/content/8/1/139
local.edoc.container-publisher-nameBioMedCentral
local.edoc.container-volume8
local.edoc.container-issue139
local.edoc.container-year2011

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