Show simple item record

2020-11-30Zeitschriftenartikel DOI: 10.25646/8895
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19
dc.contributor.authorMeinhardt, Jenny
dc.contributor.authorRadke, Josefine
dc.contributor.authorDittmayer, Carsten
dc.contributor.authorFranz, Jonas
dc.contributor.authorThomas, Carolina
dc.contributor.authorMothes, Ronja
dc.contributor.authorLaue, Michael
dc.contributor.authorSchneider, Julia
dc.contributor.authorBrünink, Sebastian
dc.contributor.authorGreuel, Selina
dc.contributor.authorLehmann, Malte
dc.contributor.authorHassan, Olga
dc.contributor.authorAschman, Tom
dc.contributor.authorSchumann, Elisa
dc.contributor.authorChua, Robert Lorenz
dc.contributor.authorConrad, Christian
dc.contributor.authorEils, Roland
dc.contributor.authorStenzel, Werner
dc.contributor.authorWindgassen, Marc
dc.contributor.authorRößler, Larissa
dc.contributor.authorGoebel, Hans-Hilmar
dc.contributor.authorGelderblom, Hans R.
dc.contributor.authorMartin, Hubert
dc.contributor.authorNitsche, Andreas
dc.contributor.authorSchulz-Schaeffer, Walter J.
dc.contributor.authorHakroush, Samy
dc.contributor.authorWinkler, Martin S.
dc.contributor.authorTampe, Björn
dc.contributor.authorScheibe, Franziska
dc.contributor.authorKörtvélyessy, Péter
dc.contributor.authorReinhold, Dirk
dc.contributor.authorSIegmund, Britta
dc.contributor.authorKühl, Anja A.
dc.contributor.authorElezkurtaj, Sefer
dc.contributor.authorHorst, David
dc.contributor.authorOesterhelweg, Lars
dc.contributor.authorTsokos, Michael
dc.contributor.authorIngold-Heppner, Barbara
dc.contributor.authorStadelmann, Christine
dc.contributor.authorDrosten, Christian
dc.contributor.authorRadbruch, Helena
dc.contributor.authorHeppner, Frank L.
dc.contributor.authorCorman, Victor Max
dc.date.accessioned2021-08-09T07:01:05Z
dc.date.available2021-08-09T07:01:05Z
dc.date.issued2020-11-30none
dc.identifier.other10.1038/s41593-020-00758-5
dc.identifier.urihttp://edoc.rki.de/176904/8607
dc.description.abstractThe newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic events throughout the body, including in the CNS, have been described. Given the neurological symptoms observed in a large majority of individuals with COVID-19, SARS-CoV-2 penetrance of the CNS is likely. By various means, we demonstrate the presence of SARS-CoV-2 RNA and protein in anatomically distinct regions of the nasopharynx and brain. Furthermore, we describe the morphological changes associated with infection such as thromboembolic ischemic infarction of the CNS and present evidence of SARS-CoV-2 neurotropism. SARS-CoV-2 can enter the nervous system by crossing the neural–mucosal interface in olfactory mucosa, exploiting the close vicinity of olfactory mucosal, endothelial and nervous tissue, including delicate olfactory and sensory nerve endings. Subsequently, SARS-CoV-2 appears to follow neuroanatomical structures, penetrating defined neuroanatomical areas including the primary respiratory and cardiovascular control center in the medulla oblongata.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.subjectDiseaseseng
dc.subjectImmunologyeng
dc.subjectMedical researcheng
dc.subjectNeuroscienceeng
dc.subjectScientific communityeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleOlfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19none
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/8607-4
dc.identifier.doihttp://dx.doi.org/10.25646/8895
dc.type.versionpublishedVersionnone
local.edoc.container-titleNature Neurosciencenone
local.edoc.container-issn1546-1726none
local.edoc.pages13none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41593-020-00758-5none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume2021none
local.edoc.container-issue24none
local.edoc.container-firstpage168none
local.edoc.container-lastpage175none
local.edoc.rki-departmentZentrum für Biologische Gefahren und Spezielle Pathogenenone
dc.description.versionPeer Reviewednone

Show simple item record