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2021-07-18Zeitschriftenartikel DOI: 10.25646/9431
The Neural Gut–Brain Axis of Pathological Protein Aggregation in Parkinson’s Disease and Its Counterpart in Peroral Prion Infections
dc.contributor.authorBeekes, Michael
dc.date.accessioned2021-12-14T13:38:45Z
dc.date.available2021-12-14T13:38:45Z
dc.date.issued2021-07-18none
dc.identifier.other10.3390/v13071394
dc.identifier.urihttp://edoc.rki.de/176904/9138
dc.description.abstractA neuropathological hallmark of Parkinson’s disease (PD) is the cerebral deposition of abnormally aggregated α-synuclein (αSyn). PD-associated αSyn (αSynPD) aggregates are assumed to act, in a prion-like manner, as proteinaceous nuclei (“seeds”) capable of self-templated propagation. Braak and colleagues put forward the idea of a neural gut-brain axis mediating the centripetal spread of αSynPD pathology from the enteric nervous system (ENS) to the brain in PD. This has sparked great interest and initiated passionate discussions both in support of and opposing the suggested hypothesis. A precedent for the spread of protein seeds or seeding from the gastro-intestinal (GI) tract to the central nervous system (CNS) had been previously revealed for pathological prion protein in peroral prion infections. This article scrutinizes the similarities and dissimilarities between the pathophysiological spread of disease-associated protein aggregation along the neural gut–brain axis in peroral prion infections and PD. On this basis, evidence supporting the proposed neural gut–brain axis in PD is concluded to be not as robust as that established for peroral prion infections. New tools for the ultrasensitive detection of αSynPD-associated seeding activity in archived or fresh human tissue samples such as real-time quaking induced conversion (RT-QuIC) or protein misfolding cyclic amplification (PMCA) assays can possibly help to address this deficit in the future.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectParkinson’s diseaseeng
dc.subjectperoral prion infectionseng
dc.subjectalpha-synucleineng
dc.subjectprion proteineng
dc.subjectseedseng
dc.subjectspreadeng
dc.subjectenteric nervous systemeng
dc.subjectvagus nerveeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleThe Neural Gut–Brain Axis of Pathological Protein Aggregation in Parkinson’s Disease and Its Counterpart in Peroral Prion Infectionsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9138-9
dc.identifier.doihttp://dx.doi.org/10.25646/9431
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirusesnone
local.edoc.container-issn1999-4915none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/1999-4915/13/7/1394none
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume13none
local.edoc.container-issue7none
local.edoc.container-year2021none
dc.description.versionPeer Reviewednone

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