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2021-05-25Zeitschriftenartikel DOI: 10.25646/9582
Nipah Virus Efficiently Replicates in Human Smooth Muscle Cells without Cytopathic Effect
dc.contributor.authorDeBuysscher, Blair L.
dc.contributor.authorScott, Dana P.
dc.contributor.authorRosenke, Rebecca
dc.contributor.authorWahl, Victoria
dc.contributor.authorFeldmann, Heinz
dc.contributor.authorPrescott, Joseph
dc.date.accessioned2022-01-28T13:09:37Z
dc.date.available2022-01-28T13:09:37Z
dc.date.issued2021-05-25none
dc.identifier.other10.3390/cells10061319
dc.identifier.urihttp://edoc.rki.de/176904/9278
dc.description.abstractNipah virus (NiV) is a highly pathogenic zoonotic virus with a broad species tropism, originating in pteropid bats. Human outbreaks of NiV disease occur almost annually, often with high case-fatality rates. The specific events that lead to pathogenesis are not well defined, but the disease has both respiratory and encephalitic components, with relapsing encephalitis occurring in some cases more than a year after initial infection. Several cell types are targets of NiV, dictated by the expression of the ephrin-B2/3 ligand on the cell’s outer membrane, which interact with the NiV surface proteins. Vascular endothelial cells (ECs) are major targets of infection. Cytopathic effects (CPE), characterized by syncytia formation and cell death, and an ensuing vasculitis, are a major feature of the disease. Smooth muscle cells (SMCs) of the tunica media that line small blood vessels are infected in humans and animal models of NiV disease, although pathology or histologic changes associated with antigen-positive SMCs have not been reported. To gain an understanding of the possible contributions that SMCs might have in the development of NiV disease, we investigated the susceptibility and potential cytopathogenic changes of human SMCs to NiV infection in vitro. SMCs were permissive for NiV infection and resulted in high titers and prolonged NiV production, despite a lack of cytopathogenicity, and in the absence of detectable ephrin-B2/3. These results indicate that SMC might be important contributors to disease by producing progeny NiV during an infection, without suffering cytopathogenic consequences.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectNipah viruseng
dc.subjectendothelial cellseng
dc.subjectsmooth muscle cellseng
dc.subjecthenipaviruseng
dc.subjectparamyxoviruseng
dc.subjectbat viruseng
dc.subjectfusioneng
dc.subjectsyncytiaeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleNipah Virus Efficiently Replicates in Human Smooth Muscle Cells without Cytopathic Effectnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9278-2
dc.identifier.doihttp://dx.doi.org/10.25646/9582
dc.type.versionpublishedVersionnone
local.edoc.container-titleCellsnone
local.edoc.container-issn2073-4409none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/2073-4409/10/6/1319none
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume10none
local.edoc.container-issue6none
local.edoc.container-year2021none
dc.description.versionPeer Reviewednone

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