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2020-10-16Zeitschriftenartikel DOI: 10.25646/9599
Impact of porcine cytomegalovirus on long‑term orthotopic cardiac xenotransplant survival
dc.contributor.authorDenner, Joachim
dc.contributor.authorLängin, Matthias
dc.contributor.authorReichart, Bruno
dc.contributor.authorKrüger, Luise
dc.contributor.authorFiebig, Uwe
dc.contributor.authorMokelke, Maren
dc.contributor.authorRadan, Julia
dc.contributor.authorMayr, Tanja
dc.contributor.authorMilusev, Anastasia
dc.contributor.authorLuther, Fabian
dc.contributor.authorSorvillo, Nicoletta
dc.contributor.authorRieben, Robert
dc.contributor.authorBrenner, Paolo
dc.contributor.authorWalz, Christoph
dc.contributor.authorWolf, Eckhard
dc.contributor.authorRoshani, Berit
dc.contributor.authorStahl‑Hennig, Christiane
dc.contributor.authorAbicht, Jan‑Michael
dc.date.accessioned2022-01-31T12:59:49Z
dc.date.available2022-01-31T12:59:49Z
dc.date.issued2020-10-16none
dc.identifier.other10.1038/s41598-020-73150-9
dc.identifier.urihttp://edoc.rki.de/176904/9294
dc.description.abstractXenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic preservation with continuous perfusion and control of post-transplantation growth of the transplant, prevention of transmission of the porcine cytomegalovirus (PCMV) plays an important role in achieving long survival times. For the first time we demonstrate that PCMV transmission in orthotopic pig heart xenotransplantation was associated with a reduced survival time of the transplant and increased levels of IL-6 and TNFα were found in the transplanted baboon. Furthermore, high levels of tPA-PAI-1 complexes were found, suggesting a complete loss of the pro-fibrinolytic properties of the endothelial cells. These data show that PCMV has an important impact on transplant survival and call for elimination of PCMV from donor pigs.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleImpact of porcine cytomegalovirus on long‑term orthotopic cardiac xenotransplant survivalnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9294-2
dc.identifier.doihttp://dx.doi.org/10.25646/9599
dc.type.versionpublishedVersionnone
local.edoc.container-titleScientific Reportsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41598-020-73150-9none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume10none
local.edoc.container-year2020none
local.edoc.container-firstpage1none
local.edoc.container-lastpage14none
dc.description.versionPeer Reviewednone

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