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2021-05-14Zeitschriftenartikel
Genome‑wide insights into population structure and host specifcity of Campylobacter jejuni
dc.contributor.authorEpping, Lennard
dc.contributor.authorWalther, Birgit
dc.contributor.authorPiro, Rosario M.
dc.contributor.authorKnüver, Marie‑Theres
dc.contributor.authorHuber, Charlotte
dc.contributor.authorThürmer, Andrea
dc.contributor.authorFlieger, Antje
dc.contributor.authorFruth, Angelika
dc.contributor.authorJanecko, Nicol
dc.contributor.authorWieler, Lothar H.
dc.contributor.authorStingl, Kerstin
dc.contributor.authorSemmler, Torsten
dc.date.accessioned2022-02-02T12:16:40Z
dc.date.available2022-02-02T12:16:40Z
dc.date.issued2021-05-14none
dc.identifier.other10.1038/s41598-021-89683-6
dc.identifier.urihttp://edoc.rki.de/176904/9343
dc.description.abstractThe zoonotic pathogen Campylobacter jejuni is among the leading causes of foodborne diseases worldwide. While C. jejuni colonises many wild animals and livestock, persistence mechanisms enabling the bacterium to adapt to host species' guts are not fully understood. In order to identify putative determinants influencing host preferences of distinct lineages, bootstrapping based on stratified random sampling combined with a k-mer-based genome-wide association was conducted on 490 genomes from diverse origins in Germany and Canada. We show a strong association of both the core and the accessory genome characteristics with distinct host animal species, indicating multiple adaptive trajectories defining the evolution of C. jejuni lifestyle preferences in different ecosystems. Here, we demonstrate that adaptation towards a specific host niche ecology is most likely a long evolutionary and multifactorial process, expressed by gene absence or presence and allele variations of core genes. Several host-specific allelic variants from different phylogenetic backgrounds, including dnaE, rpoB, ftsX or pycB play important roles for genome maintenance and metabolic pathways. Thus, variants of genes important for C. jejuni to cope with specific ecological niches or hosts may be useful markers for both surveillance and future pathogen intervention strategies.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleGenome‑wide insights into population structure and host specifcity of Campylobacter jejuninone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9343-0
dc.type.versionpublishedVersionnone
local.edoc.container-titleScientific Reportsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41598-021-89683-6none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume11none
local.edoc.container-year2021none
local.edoc.container-firstpage1none
local.edoc.container-lastpage15none
dc.description.versionPeer Reviewednone

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