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2021-12-21Zeitschriftenartikel
Human Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany
dc.contributor.authorFrank, Christina
dc.contributor.authorWickel, Jonathan
dc.contributor.authorBrämer, Dirk
dc.contributor.authorMatschke, Jakob
dc.contributor.authorIbe, Richard
dc.contributor.authorGazivoda, Caroline
dc.contributor.authorGünther, Albrecht
dc.contributor.authorHartmann, Christian
dc.contributor.authorRehn, Kordt
dc.contributor.authorCadar, Daniel
dc.contributor.authorMayer, Thomas E.
dc.contributor.authorPörtner, Kirsten
dc.contributor.authorWilking, Hendrik
dc.contributor.authorSchmidt-Chanasit, Jonas
dc.contributor.authorTappe, Dennis
dc.date.accessioned2022-03-16T07:13:04Z
dc.date.available2022-03-16T07:13:04Z
dc.date.issued2021-12-21none
dc.identifier.other10.1080/22221751.2021.2007737
dc.identifier.urihttp://edoc.rki.de/176904/9501
dc.description.abstractIn 2021, three encephalitis cases due to the Borna disease virus 1 (BoDV-1) were diagnosed in the north and east of Germany. The patients were from the states of Thuringia, Saxony-Anhalt, and Lower Saxony. All were residents of known endemic areas for animal Borna disease but without prior diagnosed human cases. Except for one recently detected case in the state of Brandenburg, all >30 notified cases had occurred in, or were linked to, the southern state of Bavaria. Of the three detected cases described here, two infections were acute, while one infection was diagnosed retrospectively from archived brain autopsy tissue samples. One of the acute cases survived, but is permanently disabled. The cases were diagnosed by various techniques (serology, molecular assays, and immunohistology) following a validated testing scheme and adhering to a proposed case definition. Two cases were classified as confirmed BoDV-1 encephalitis, while one case was a probable infection with positive serology and typical brain magnetic resonance imaging, but without molecular confirmation. Of the three cases, one full virus genome sequence could be recovered. Our report highlights the need for awareness of a BoDV-1 etiology in cryptic encephalitis cases in all areas with known animal Borna disease endemicity in Europe, including virus-endemic regions in Austria, Liechtenstein, and Switzerland. BoDV-1 should be actively tested for in acute encephalitis cases with residence or rural exposure history in known Borna disease-endemic areas.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectBorna diseaseeng
dc.subjectBorna disease virus 1eng
dc.subjectbornaviruseng
dc.subjectsurveillanceeng
dc.subjectepidemiologyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleHuman Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germanynone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9501-1
dc.type.versionpublishedVersionnone
local.edoc.container-titleEmerging Microbes & Infectionsnone
local.edoc.container-issn2222-1751none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.tandfonline.com/doi/ref/10.1080/22221751.2021.2007737?scroll=topnone
local.edoc.container-publisher-nameInforma UK Limitednone
local.edoc.container-volume11none
local.edoc.container-issue1none
local.edoc.container-year2021none
local.edoc.container-firstpage7none
local.edoc.container-lastpage13none
dc.description.versionPeer Reviewednone

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