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Browsing by Author "Niemann, Stefan"
Now showing items 1-13 of 13
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2018-01-08ZeitschriftenartikelA cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study Walker, Timothy M.; Merker, Matthias; Knoblauch, Astrid M.; Helbling, Peter; Schoch, Otto D.; van der Werf, Marieke J.; Kranzer, Katharina; Fiebig, Lena; Kröger, Stefan; Haas, Walter; Hoffmann, Harald; Indra, Alexander; Egli, Adrian; Cirillo, Daniela M.; Robert, Jérôme; Rogers, Thomas R.; Groenheit, Ramona; Mengshoel, Anne T.; Mathys, Vanessa; Haanperä, Marjo; van Soolingen, Dick; Niemann, Stefan; Böttger, Erik C.; Keller, Peter M.; MDR-TB Cluster ConsortiumBackground The risk of tuberculosis outbreaks among people fleeing hardship for refuge in Europe is heightened. We describe the cross-border European response to an outbreak of multidrug-resistant tuberculosis among ...
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2017-01-12ZeitschriftenartikelA joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: lessons learnt Fiebig, Lena; Kohl, Thomas A.; Popovici, O.; Mühlenfeld, M.; Indra, A.; Homorodean, D.; Chiotan, D.; Richter, E.; Rüsch-Gerdes, Sabine; Schmidgruber, B.; Beckert, P.; Hauer, Barbara; Niemann, Stefan; Allerberger, Franz; Haas, WalterMolecular surveillance of multidrug-resistant tuberculosis (MDR-TB) using 24-loci MIRU-VNTR in the European Union suggests the occurrence of international transmission. In early 2014, Austria detected a molecular MDR-TB ...
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2018-11-29ZeitschriftenartikelEin internationales MDR-TB-Cluster bei jungen Geflüchteten vom Horn von Afrika Erfahrungen und Erkenntnisse aus der Perspektive DeutschlandsKröger, Stefan; Hauer, Barbara; Haas, Walter; Fiebig, Lena; Charles, T.; Kranzer, Katharina; Merker, M.; Niemann, Stefan; Schacher, R.; Bauer, C.; Geiger, F.; Hendrickx, D.; Wagner-Wiening, ChristianeSeit Frühjahr 2016 wurden in mehreren Mitgliedsstaaten der Europäischen Union (EU) und der Schweiz Erkrankungen an MDR-TB beobachtet, die ein seltenes Resistenzprofil gegenüber Zweitrangmedikamenten aufweisen. Dies veranlasste ...
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2019-03-14ZeitschriftenartikelGemeinsame Stellungnahme zur neuen Empfehlung der WHO zur Behandlung der multiresistenten und Rifampicin-resistenten Tuberkulose Maurer, Florian; Bauer, Torsten; Diel, Roland; Häcker, Brit; Lange, Christoph; Niemann, Stefan; Otto-Knapp, Ralf; Schönfeld, NicolasDie Entwicklung von Medikamentenresistenz ist global derzeit eines der größten Hindernisse im Kampf gegen TB. Die Problematik resistenter TB ist auch in Deutschland präsent. Zwar sind die Resistenzraten in den letzten ...
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2012-07-02ZeitschriftenartikelHigh Resolution Discrimination of Clinical Mycobacterium tuberculosis Complex Strains Based on Single Nucleotide Polymorphisms Homolka, Susanne; Projahn, Michaela; Feuerriegel, Silke; Ubben, Tanja; Diel, Roland; Nübel, Ulrich; Niemann, StefanRecently, the diversity of the Mycobacterium tuberculosis complex (MTBC) population structure has been described in detail. Based on geographical separation and specific host pathogen co-evolution shaping MTBC virulence ...
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2020-01-14ZeitschriftenartikelImproving tuberculosis surveillance by detecting international transmission using publicly available whole genome sequencing data Sanchini, Andrea; Jandrasits, Christine; Tembrockhaus, Julius; Kohl, Thomas Andreas; Utpatel, Christian; Maurer, Florian P.; Niemann, Stefan; Haas, Walter; Renard, Bernhard Y.; Kröger, StefanImproving the surveillance of tuberculosis (TB) is one of the eight core activities identified by the World Health Organization (WHO) and the European Respiratory Society to achieve TB elimination, defined as less than one ...
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2017-11-22ZeitschriftenartikelIntegration of molecular typing results into tuberculosis surveillance in Germany—A pilot study Andrés, Marta; Göhring-Zwacka, Elke; Fiebig, Lena; Priwitzer, Martin; Richter, Elvira; Rüsch-Gerdes, Sabine; Haas, Walter; Niemann, Stefan; Brodhun, BonitaAn integrated molecular surveillance for tuberculosis (TB) improves the understanding of ongoing TB transmission by combining molecular typing and epidemiological data. However, the implementation of an integrated molecular ...
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2013-06-01ZeitschriftenartikelNovel Mycobacterium tuberculosis Complex Isolate from a Wild Chimpanzee Coscolla, Mireia; Lewin, Astrid; Metzger, Sonja; Mätz-Rennsing, Kerstin; Calvignac-Spencer, Sébastien; Nitsche, Andreas; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Niemann, Stefan; Parkhill, Julian; Couacy-Hymann, Emmanuel; Feldman, Julia; Comas, Iñaki; Boesch, Christophe; Gagneux, Sebastien; Leendertz, FabianTuberculosis (TB) is caused by gram-positive bacteria known as the Mycobacterium tuberculosis complex (MTBC). MTBC include several human-associated lineages and several variants adapted to domestic and, more rarely, wild ...
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2021-03-18ZeitschriftenartikelSchnelle Resistenzvorhersage gegenüber TB-Medikamenten der Standard- und Nicht-Standardtherapie: Methodenevaluation zur gezielten Genomsequenzierung aus klinischem Primärmaterial Feuerriegel, Silke; Dreyer, Viola; Andres, Sönke; Kohl, Thomas A.; Utpate, Christian; Heyckendorf, Jan; Maurer, Florian P.; Niemann, StefanMulti- und extensiv-resistente Mycobacterium tuberculosis Komplex-Stämme stellen weltweit eine zunehmende Herausforderung für die Kontrolle der Tuberkulose dar. Eine umfangreiche Empfindlichkeitstestung ist essenziell für ...
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2018-06-14ZeitschriftenartikelSmear Microscopy for Diagnosis of Pulmonary Tuberculosis in Eastern Sudan Shuaib, Yassir A.; Khalil, Eltahir A. G.; Schaible, Ulrich E.; Wieler, Lothar H.; Bakheit, Mohammed A. M.; Mohamed-Noor, Saad E.; Abdalla, Mohamed A.; Homolka, Susanne; Andres, Sönke; Hillemann, Doris; Lonnroth, Knut; Richter, Elvira; Niemann, Stefan; Kranzer, KatharinaBackground. In Sudan, tuberculosis diagnosis largely relies on clinical symptoms and smear microscopy as in many other low- and middle-income countries. The aim of this study was to investigate the positive predictive value ...
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2015-10-07ZeitschriftenartikelTracing the Spread of Clostridium difficile Ribotype 027 in Germany Based on Bacterial Genome Sequences Steglich, Matthias; Nitsche, Andreas; Müller, Lutz von; Herrmann, Mathias; Kohl, Thomas A.; Niemann, Stefan; Nübel, UlrichWe applied whole-genome sequencing to reconstruct the spatial and temporal dynamics underpinning the expansion of Clostridium difficile ribotype 027 in Germany. Based on re-sequencing of genomes from 57 clinical C. difficile ...
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2009-12-04ZeitschriftenartikelTransmission dynamics of pulmonary tuberculosis between autochthonous and immigrant sub-populations Barniol, Judit; Niemann, Stefan; Louis, Valérie R; Brodhun, Bonita; Dreweck, Caroline; Richter, Elvira; Becher, Heiko; Haas, Walter; Junghanss, ThomasBackground: The overall incidence of tuberculosis (TB) in Western Europe has been declining since the 19th Century. However, immigrant sub-groups from high-prevalence countries are slowing down this trend. The aim of this ...
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2013-02-12ZeitschriftenartikelWhole Genome Sequencing versus Traditional Genotyping for Investigation of a Mycobacterium tuberculosis Outbreak: A Longitudinal Molecular Epidemiological Study Roetzer, Andreas; Diel, Roland; Kohl, Thomas A.; Rückert, Christian; Nübel, Ulrich; Blom, Jochen; Wirth, Thierry; Jaenicke, Sebastian; Schuback, Sieglinde; Rüsch-Gerdes, Sabine; Supply, Philip; Kalinowski, Jörn; Niemann, StefanBackground: Understanding Mycobacterium tuberculosis (Mtb) transmission is essential to guide efficient tuberculosis control strategies. Traditional strain typing lacks sufficient discriminatory power to resolve large ...