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Browsing by Author "Hutloff, Andreas"
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2016-12-30ZeitschriftenartikelAdequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model Fuhrmann, Franziska; Lischke, Timo; Gross, Fridolin; Scheel, Tobias; Bauer, Laura; Kalim, Khalid Wasim; Radbruch, Andreas; Herzel, Hanspeter; Hutloff, Andreas; Baumgrass, RiaThe IL-2/IL-2Ralpha (CD25) axis is of central importance for the interplay of effector and regulatory T cells. Nevertheless, the question how different antigen loads are translated into appropriate IL-2 production to ensure ...
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2003-01-01ZeitschriftenartikelExpression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10 Löhning, Max; Hutloff, Andreas; Kallinich, Tilmann; Mages, Hans Werner; Bonhagen, Kerstin; Radbruch, Andreas; Hamelmann, Eckard; Kroczek, RichardThe studies performed to date analyzed the overall participation of the inducible costimulator (ICOS) in model diseases, but did not yield information on the nature and function of ICOS-expressing T cells in vivo. We ...
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2010-05-24ZeitschriftenartikelInducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis Frey, Oliver; Meisel, Juliane; Hutloff, Andreas; Bonhagen, Kerstin; Bruns, Lisa; Kroczek, Richard; Morawietz, Lars; Kamradt, ThomasObjectives: Inducible costimulator (ICOS) and its ligand (ICOSL) regulate T and B cell responses. Glucose-6-phosphate isomerase (G6PI)-induced arthritis requires T and B lymphocytes. It was hypothesised that blocking ...
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2016-02-26ZeitschriftenartikelLocal T/B cooperation in inflamed tissues is supported by T follicular helper-like cells Van, Dana Vu; Beier, Katja C.; Pietzke, Lea-Jean; Baz, Maysun S. Al; Feist, Randi K.; Gurka, Stephanie; Hamelmann, Eckard; Kroczek, Richard; Hutloff, AndreasAutoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare ...
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2014-07-28ZeitschriftenartikelOntogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα Becker, Martina; Güttler, Steffen; Bachem, Annabell; Hartung, Evelyn; Mora, Ahmed; Jäkel, Anika; Hutloff, Andreas; Henn, Volker; Mages, Hans Werner; Gurka, Stephanie; Kroczek, RichardIn the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor ...
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2010-11-11ZeitschriftenartikelReduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE Gültner, Sandra; Kuhlmann, Tanja; Hesse, Amke; Weber, Jan P.; Riemer, Constanze; Baier, Michael; Hutloff, AndreasThe αLβ2-integrin LFA-1 (CD11a/CD18) is known as an important molecule for leukocyte migration. However, the precise role of LFA-1 in the pathogenesis of EAE has so far remained unclear. We describe here the disease ...