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Browsing by Author "Grossegesse, Marica"
Now showing items 1-14 of 14
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2017-10-13ZeitschriftenartikelA Next-Generation Sequencing Approach Uncovers Viral Transcripts Incorporated in Poxvirus Virions Grossegesse, Marica; Döllinger, Jörg; Haldemann, Berit; Schaade, Lars; Nitsche, AndreasTranscripts are known to be incorporated in particles of DNA viruses belonging to the families of Herpesviridae and Mimiviridae, but the presence of transcripts in other DNA viruses, such as poxviruses, has not been analyzed ...
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2021-03-24ZeitschriftenartikelAmantadine Inhibits SARS-CoV-2 In Vitro FInk, Klaus; Nitsche, Andreas; Neumann, Markus; Grossegesse, Marica; Eisele, Karl-Heinz; Danysz, WojciechSince the SARS-CoV-2 pandemic started in late 2019, the search for protective vaccines and for drug treatments has become mandatory to fight the global health emergency. Travel restrictions,social distancing, and face masks ...
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2022-11-17ZeitschriftenartikelAnalysis of two choir outbreaks acting in concert to characterize long- range transmission risks through SARS-CoV-2, Berlin, Germany, 2020 Reichert, Felix; Stier, Oliver; Hartmann, Anne; Ruscher, Claudia; Brinkmann, Annika; Grossegesse, Marica; Neumann, Markus; Werber, Dirk; Hausner, Marius; Kunze, Mareike; Weiß, Bettina; Michel, Janine; Nitsche, Andreas; an der Heiden, Matthias; Kriegel, Martin; Corman, Victor Max; Jones, Terry Carleton; Drosten, Christian; Brommann, Tobias; Buchholz, UdoBackground Superspreading events are important drivers of the SARS-CoV-2 pandemic and long-range (LR) transmission is believed to play a major role. We investigated two choir outbreaks with different attack rates (AR) ...
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2021-02-22ZeitschriftenartikelApplication of spectral library prediction for parallel reaction monitoring of viral peptides Grossegesse, Marica; Nitsche, Andreas; Schaade, Lars; Döllinger, JörgA major part of the analysis of parallel reaction monitoring (PRM) data is the comparison of observed fragment ion intensities to a library spectrum. Classically, these libraries are generated by data-dependent acquisition ...
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2017-11-10ZeitschriftenartikelCombined Proteomics/Genomics Approach Reveals Proteomic Changes of Mature Virions as a Novel Poxvirus Adaptation Mechanism Grossegesse, Marica; Döllinger, Jörg; Tyshaieva, Alona; Schaade, Lars; Nitsche, AndreasDNA viruses, like poxviruses, possess a highly stable genome, suggesting that adaptation of virus particles to specific cell types is not restricted to genomic changes. Cowpox viruses are zoonotic poxviruses with an ...
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2021-11-04ZeitschriftenartikelEstablishment of a specimen panel for the decentralised technical evaluation of the sensitivity of 31 rapid diagnostic tests for SARS-CoV-2 antigen, Germany, September 2020 to April 2021 Puyskens, Andreas; Krause, Eva; Michel, Janine; Nübling, C. Micha; Scheiblauer, Heinrich; Bourquain, Daniel; Grossegesse, Marica; Valusenko, Roman; Corman, Victor M.; Drosten, Christian; Zwirglmaier, Katrin; Wölfel, Roman; Lange, Constanze; Kramer, Jan; Friesen, Johannes; Ignatius, Ralf; Müller, Michael; Schmidt-Chanasit, Jonas; Emmerich, Petra; Schaade, Lars; Nitsche, AndreasIntroduction The detection of SARS-CoV-2 with rapid diagnostic tests (RDT) has become an important tool to identify infected people and break infection chains. These RDT are usually based on antigen detection in a lateral ...
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2022-03-03ZeitschriftenartikelEvaluation of a commercial ELISA as alternative to plaque reduction neutralization test to detect neutralizing antibodies against SARS-CoV-2 Hofmann, Natalie; Grossegesse, Marica; Neumann, Markus; Schaade, Lars; Nitsche, AndreasHigh-throughput detection of neutralizing antibodies against SARS-CoV-2 presents a valuable tool for vaccine trials or investigations of population immunity. We evaluate the performance of the first commercial surrogate ...
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2018-01-29ZeitschriftenartikelGlobal ubiquitination analysis reveals extensive modification and proteasomal degradation of cowpox virus proteins, but preservation of viral cores Grossegesse, Marica; Doellinger, Joerg; Fritsch, Annemarie; Laue, Michael; Piesker, Janett; Schaade, Lars; Nitsche, AndreasThe emergence of Variola virus-like viruses by natural evolution of zoonotic Orthopoxviruses, like Cowpox virus (CPXV), is a global health threat. The proteasome is essential for poxvirus replication, making the viral ...
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2022-01-24ZeitschriftenartikelLongitudinal SARS-CoV-2 seroepidemiological investigation among healthcare workers at a tertiary care hospital in Germany Tomczyk, Sara; Hönning, Alexander; Hermes, Julia; Grossegesse, Marica; Hofmann, Natalie; Michel, Janine; Neumann, Markus; Nitsche, Andreas; Hoppe, Berthold; Eckmanns, Tim; Schmidt‑Traub, Hajo; Zappel, KristinaBackground: SARS-CoV-2 cases in Germany increased in early March 2020. By April 2020, cases among health care workers (HCW) were detected across departments at a tertiary care hospital in Berlin, prompting a longitudinal ...
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2023-04-02ZeitschriftenartikelMonitoring the SARS-CoV-2 Pandemic: Prevalence of Antibodies in a Large, Repetitive Cross-Sectional Study of Blood Donors in Germany—Results from the SeBluCo Study 2020–2022 Offergeld, Ruth; Preußel, Karina; Zeiler, Thomas; Aurich, Konstanze; Baumann-Baretti, Barbara I.; Ciesek, Sandra; Corman, Victor M.; Dienst, Viktoria; Drosten, Christian; Görg, Siegfried; Greinacher, Andreas; Grossegesse, Marica; Haller, Sebastian; Heuft, Hans-Gert; Hofmann, Natalie; Horn, Peter A.; Houareau, Claudia; Gülec, Ilay; Jiménez Klingberg, Carlos Luis; Juhl, David; Lindemann, Monika; Martin, Silke; Neuhauser, Hannelore K.; Nitsche, Andreas; Ohme, Julia; Peine, Sven; Sachs, Ulrich J.; Schaade, Lars; Schäfer, Richard; Scheiblauer, Heinrich; Schlaud, Martin; Schmidt, Michael; Umhau, Markus; Vollmer, Tanja; Wagner, Franz F.; Wieler, Lothar H.; Wilking, Hendrik; Ziemann, Malte; Zimmermann, Marlow; an der Heiden, MatthiasSARS-CoV-2 serosurveillance is important to adapt infection control measures and estimate the degree of underreporting. Blood donor samples can be used as a proxy for the healthy adult population. In a repeated cross-sectional ...
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2020-10-22ZeitschriftenartikelPerspective on Proteomics for Virus Detection in Clinical Samples Grossegesse, Marica; Hartkopf, Felix; Nitsche, Andreas; Schaade, Lars; Doellinger, Joerg; Muth, ThiloOne of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics ...
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2019-06-08ZeitschriftenartikelPurple: A Computational Workflow for Strategic Selection of Peptides for Viral Diagnostics Using MS-Based Targeted Proteomics Lechner, Johanna; Hartkopf, Felix; Hiort, Pauline; Nitsche, Andreas; Grossegesse, Marica; Doellinger, Joerg; Renard, Bernhard Y.; Muth, ThiloEmerging virus diseases present a global threat to public health. To detect viral pathogens in time-critical scenarios, accurate and fast diagnostic assays are required. Such assays can now be established using mass ...
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2021-06-02ZeitschriftenartikelResource-efficient internally controlled in-house real-time PCR detection of SARS-CoV-2 Michel, Janine; Neumann, Markus; Krause, Eva; Rinner, Thomas; Muzeniek, Therese; Grossegesse, Marica; Hille, Georg; Schwarz, Franziska; Puyskens, Andreas; Förster, Sophie; Biere, Barbara; Bourquain, Daniel; Domingo, Cristina; Brinkmann, Annika; Schaade, Lars; Schrick, Livia; Nitsche, AndreasBackground The reliable detection of SARS-CoV-2 has become one of the most important contributions to COVID-19 crisis management. With the publication of the first sequences of SARS-CoV-2, several diagnostic PCR assays ...
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2022-10-27ZeitschriftenartikelUntersuchung und Eindämmung eines SARS-CoV-2-Alpha-Ausbruchs in einer Pflegeeinrichtung im Landkreis Dithmarschen, Juni 2021 Sperle, Ida; Hofmann, Alexandra; Schönfeld, Viktoria; Hellenbrand, Wiebke; Sandfort, Mirco; Grossegesse, Marica; Hofmann, Natalie; Michel, Janine; Nitsche, Andreas; Brinkmann, Annika; Kohl, Claudia; Dorner, Brigitte; Meyer, Tanja; Stern, Daniel; Gadomski, Claudia; Harder, ThomasBewohnende und Personal in Pflegeeinrichtungen gehören zu den Personengruppen, die ab dem 27.12.2020 in Deutschland priorisiert die COVID-19-Impfung erhielten. Diese zeigte eine gute Wirksamkeit hinsichtlich des Schutzes ...