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Browsing by Author "Ignatius, Ralf"
Now showing items 1-13 of 13
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2007-09-06ZeitschriftenartikelAcute childhood diarrhoea in northern Ghana: epidemiological, clinical and microbiological characteristics Reither, Klaus; Ignatius, Ralf; Weitzel, Thomas; Seidu-Korkor, Andrew; Anyidoho, Louis; Saad, Eiman; Djie-Maletz, Andrea; Ziniel, Peter; Amoo-Sakyi, Felicia; Danikuu, Francis; Danour, Stephen; Otchwemah, Rowland N.; Schreier, Eckart; Bienzle, Ulrich; Stark, Klaus; Mockenhaupt, Frank P.Background: Acute diarrhoea is a major cause of childhood morbidity and mortality in sub-Saharan Africa. Its microbiological causes and clinico-epidemiological aspects were examined during the dry season 2005/6 in Tamale, ...
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2008-10-22ZeitschriftenartikelAetiology of community-acquired, acute gastroenteritis in hospitalised adults: a prospective cohort study Jansen, Andreas; Stark, Klaus; Kunkel, Jan; Schreier, Eckart; Ignatius, Ralf; Liesenfeld, Oliver; Werber, Dirk; Göbel, Ulf B; Zeitz, Martin; Schneider, ThomasBackground: The aetiology of severe gastroenteritis leading to hospitalisation in adults frequently remains unclear. Our objective was to study the causes and characteristics of community-acquired, acute gastroenteritis ...
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2007-06-01ZeitschriftenartikelClostridium-difficile-assoziierte Diarrhö: Ein zunehmendes klinisches Problem durch neue hochvirulente Erreger Schneider, Thomas; Eckmanns, Tim; Ignatius, Ralf; Weist, Klaus; Liesenfeld, OliverEinleitung: Clostridium-difficile-assoziierte Erkrankungen (CDAD) sind ein zunehmendes Problem, insbesondere bei der Versorgung schwer kranker und alter Patienten. Methoden: Eine selektive Literaturübersicht wurde mittels ...
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2021-11-04ZeitschriftenartikelEstablishment of a specimen panel for the decentralised technical evaluation of the sensitivity of 31 rapid diagnostic tests for SARS-CoV-2 antigen, Germany, September 2020 to April 2021 Puyskens, Andreas; Krause, Eva; Michel, Janine; Nübling, C. Micha; Scheiblauer, Heinrich; Bourquain, Daniel; Grossegesse, Marica; Valusenko, Roman; Corman, Victor M.; Drosten, Christian; Zwirglmaier, Katrin; Wölfel, Roman; Lange, Constanze; Kramer, Jan; Friesen, Johannes; Ignatius, Ralf; Müller, Michael; Schmidt-Chanasit, Jonas; Emmerich, Petra; Schaade, Lars; Nitsche, AndreasIntroduction The detection of SARS-CoV-2 with rapid diagnostic tests (RDT) has become an important tool to identify infected people and break infection chains. These RDT are usually based on antigen detection in a lateral ...
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2022-12-26ZeitschriftenartikelExtensive testing of a multi-locus sequence typing scheme for Giardia duodenalis assemblage A confirms its good discriminatory power Klotz, Christian; Sannella, Anna Rosa; Weisz, Filip; Chaudhry, Umer; Sroka, Jacek; Tůmová, Pavla; Nohýnková, Eva; Ignatius, Ralf; Aebischer, Toni; Betson, Martha; Troell, Karin; Cacciò, SimoneBackground The flagellated parasite Giardia duodenalis is a major and global cause of diarrhoeal disease. Eight genetically very distinct groups, known as assemblages A to H, have been recognized in the G. duodenalis ...
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2013-04-15ZeitschriftenartikelGiardia duodenalis arginine deiminase modulates the phenotype and cytokine secretion of human dendritic cells by depletion of arginine and formation of ammonia Banik, Stefanie; Viveros, Pablo Renner; Seeber, Frank; Klotz, Christian; Ignatius, Ralf; Aebischer, ToniDepletion of arginine is a recognized strategy that pathogens use to evade immune effector mechanisms. Depletion depends on microbial enzymes such as arginases, which are considered virulence factors. The effect is mostly ...
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2012-06-12ZeitschriftenartikelHigh Prevalence of Giardia duodenalis Assemblage B Infection and Association with Underweight in Rwandan Children Ignatius, Ralf; Gahutu, Jean Bosco; Klotz, Christian; Steininger, Christian; Shyirambere, Cyprien; Lyng, Michel; Musemakweri, Andre; Aebischer, Toni; Martus, Peter; Harms, Gundel; Mockenhaupt, Frank P.Background: Giardia duodenalis is highly endemic in East Africa but its effects on child health, particularly of submicroscopic infections, i.e., those below the threshold of microscopy, and of genetic subgroups ...
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2013-08-19ZeitschriftenartikelHigh Sensitivity of Giardia duodenalis to Tetrahydrolipstatin (Orlistat) In Vitro Hahn, Juliane; Seeber, Frank; Kolodziej, Herbert; Ignatius, Ralf; Laue, Michael; Aebischer, Toni; Klotz, ChristianGiardiasis, a gastrointestinal disease caused by Giardia duodenalis, is currently treated mainly with nitroimidazoles, primarily metronidazole (MTZ). Treatment failure rates of up to 20 percent reflect the compelling need ...
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2021-05-21ZeitschriftenartikelImplementation of Automated Blood Culture With Quality Assurance in a Resource-Limited Setting von Laer, Anja; N'Guessan, Micheline Ahou; Touré, Fidèle Sounan; Nowak, Kathrin; Groeschner, Karin; Ignatius, Ralf; Friesen, Johannes; Tomczyk, Sara; Leendertz, Fabian H.; Eckmanns, Tim; Akoua, ChantalBackground: Blood cultures (BC) have a high clinical relevance and are a priority specimen for surveillance of antimicrobial resistance. Manual BC are still most frequently used in resource-limited settings. Data on automated ...
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2013-11-04ZeitschriftenartikelIncreased expression of CD25, CD83, and CD86, and secretion of IL-12, IL-23, and IL-10 by human dendritic cells incubated in the presence of Toll-like receptor 2 ligands and Giardia duodenalis Obendorf, Janine; Viveros, Pablo Renner; Fehlings, Michael; Klotz, Christian; Aebischer, Toni; Ignatius, RalfBackground: Effects of Giardia duodenalis on dendritic cell (DC) functions may contribute to the pathogenesis of chronic giardiasis. G. duodenalis lysate has been shown to inhibit the activation of murine DCs through ...
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2019-02-21ZeitschriftenartikelNo evidence of carbapenemase-producing Enterobacteriaceae in stool samples of 1,544 asylum seekers arriving in Rhineland-Palatinate, Germany, April 2016 to March, 2017 Ehlkes, Lutz; Pfeifer, Yvonne; Werner, Guido; Ignatius, Ralf; Vogt, Manfred; Eckmanns, Tim; Zanger, Philipp; Walter, JanIntroduction: Since 2015, increased migration from Asia and Africa to Europe has raised public health concerns about potential importation of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE), specifically ...
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2021-03-25ZeitschriftenartikelSuitability of current typing procedures to identify epidemiologically linked human Giardia duodenalis isolates Woschke, Andreas; Faber, Mirko; Stark, Klaus; Holtfreter, Martha; Mockenhaupt, Frank; Richter, Joachim; Regnath, Thomas; Sobottka, Ingo; Reiter-Owona, Ingrid; Diefenbach, Andreas; Gosten-Heinrich, Petra; Friesen, Johannes; Ignatius, Ralf; Aebischer, Toni; Klotz, ChristianBackground Giardia duodenalis is a leading cause of gastroenteritis worldwide. Humans are mainly infected by two different subtypes, i.e., assemblage A and B. Genotyping is hampered by allelic sequence heterozygosity (ASH) ...
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2013-06-21ZeitschriftenartikelThe Attenuated Brucella abortus Strain 19 Invades, Persists in, and Activates Human Dendritic Cells, and Induces the Secretion of IL-12p70 but Not IL-23 Weinhold, Mario; Eisenblätter, Martin; Jasny, Edith; Fehlings, Michael; Finke, Antje; Gayum, Hermine; Rüschendorf, Ursula; Viveros, Pablo Renner; Moos, Verena; Allers, Kristina; Schneider, Thomas; Schaible, Ulrich E.; Schumann, Ralf R.; Mielke, Martin; Ignatius, RalfBackground: Bacterial vectors have been proposed as novel vaccine strategies to induce strong cellular immunity. Attenuated strains of Brucella abortus comprise promising vector candidates since they have the potential ...