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Anzeige der Publikationen 1549-1568 von 11409
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2019-03-29ZeitschriftenartikelCross-Protective Potential and Protection-Relevant Immune Mechanisms of Whole Inactivated Influenza Virus Vaccines Are Determined by Adjuvants and Route of Immunization Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a ...
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2009-02-25ZeitschriftenartikelCross-talk between type three secretion system and metabolism in Yersinia. Pathogenic yersiniae utilize a type three secretion system (T3SS) to inject Yop proteins into host cells in order to undermine their immune response. YscM1 and YscM2 proteins have been reported to be functionally equivalent ...
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2012-03-26ZeitschriftenartikelCross-transmission rates of enterococcal isolates among newborns in a neonatal intensive care unit Enterococci are important pathogens causing nosocomial infections and patients at risk include also premature babies requiring intensive care treatment. Our aim was to assess occurrence and cross transmission rates of ...
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2013-10-09ZeitschriftenartikelCryo FIB-SEM: Volume imaging of cellular ultrastructure in native frozen specimens Volume microscopy at high resolution is increasingly required to better understand cellular functions in the context of three-dimensional assemblies. Focused ion beam (FIB) milling for serial block face imaging in the ...
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2021-01-15ZeitschriftenartikelCryptococcus bacillisporus (VGIII) Meningoencephalitis Acquired in Santa Cruz, Bolivia We describe a case of chronic meningoencephalitis with hydrocephalus caused by Crypto- coccus bacillisporus (VGIII) in an immunocompetent patient from Santa Cruz, Bolivia. This first report of a member of the Cryptococcus ...
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2023-01-18ZeitschriftenartikelCrystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1 Botulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A–G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. The ...
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2009-08-22ZeitschriftenartikelCrystallization and preliminary X-ray diffraction data of an LNA 7-mer duplex derived from a ricin aptamer Locked nucleic acids (LNAs) are modified nucleic acids which contain a modified sugar such as beta-D-2'-O,4'-C methylene-bridged ribofuranose or other sugar derivatives in LNA analogues. The beta-D-2'-O,4'-C methylene ...
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2017-08-18ZeitschriftenartikelCultivable bacterial microbiota from choanae of free-living birds captured in Slovenia We have analysed the structure of cultivable choanal microbiota from free-living birds in relation to bird diet, its richness and the relative number of opportunistic bacteria acquired from the environment. For this purpose, ...
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2009-07-01ZeitschriftenartikelCumulative HIV Viremia during Highly Active Antiretroviral Therapy Is a Strong Predictorof AIDS‐Related Lymphoma Background.AIDS‐related lymphoma contributes to significant morbidity and mortality among human immunodeficiency virus (HIV)–infected patients receiving highly active antiretroviral therapy (HAART). We assessed the predictive ...
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2015-04-10ZeitschriftenartikelCurrent major depressive syndrome measured with the Patient Health Questionnaire-9 (PHQ-9) and the Composite International Diagnostic Interview (CIDI): results from a cross-sectional population-based study of adults in Germany Background: Prevalence estimates for depression vary considerably by the type of assessment instrument, and there is limited information on their overlap in population-based samples. Our aim was to compare the Patient ...
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2015-04-01ZeitschriftenartikelCurrent practices in immunisation policymaking in European countries ECDC TECHNICAL REPORTThis report describes and summarises the national processes for vaccine policymaking currently implemented in EU/EEA countries, the roles of the so-called national technical advisory groups (NITAGs) in the Member States ...
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2015-07-02ZeitschriftenartikelCurrent prevalence of multidrug-resistant organisms in long-term care facilities in the Rhine-Main district, Germany, 2013 Multidrug-resistant organisms (MDRO) and in particular multidrug-resistant Gram-negative organisms (MRGN) are an increasing problem in hospital care. However, data on the current prevalence of MDRO in long-term care ...
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2016-02-11Berichte und sonstige TexteCurrent status of allergy prevalence in Germany The lifetime prevalence of allergic diseases in adults in Germany [self-reported doctor diagnosed allergic diseases, Study on Adult Health in Germany (Studie zur Gesundheit Erwachsener in Deutschland, DEGS1, 2008–2011) of ...
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2012-03-01ZeitschriftenartikelCurrent Trends of Emergence and Spread of Vancomycin-Resistant Enterococci
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2007-08-31ZeitschriftenartikelCytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors Background: Stem cell transplantation as therapy for hematological disorders is often hampered by severe graft-versus-host-disease. This may be reduced by umbilical cord blood transplantation, an effect that has been ...
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2018-07-25ZeitschriftenartikelCytomegalovirus (CMV) seroprevalence in the adult population of Germany Background: Infection with cytomegalovirus (CMV) remains asymptomatic in most immunocompetent hosts, but is the leading cause of congenital viral infection worldwide and can be life-threatening in immunocompromised ...
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2019-08-01ZeitschriftenartikelCytomegalovirus distribution and evolution in hominines Herpesviruses are thought to have evolved in very close association with their hosts. This is notably the case for cytomegaloviruses (CMVs; genus Cytomegalovirus) infecting primates, which exhibit a strong signal of ...
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2013-08-08ZeitschriftenartikelCytomegalovirus Downregulates IRE1 to Repress the Unfolded Protein Response During viral infection, a massive demand for viral glycoproteins can overwhelm the capacity of the protein folding and quality control machinery, leading to an accumulation of unfolded proteins in the endoplasmic reticulum ...
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2011-04-06ZeitschriftenartikelCytomegalovirus e127 protein interacts with the inhibitory CD200 receptor. CD200 is a cell surface glycoprotein that binds an inhibitory receptor (CD200R) on myeloid cells. CD200 orthologues are present in many species of virus, and we show that the rat cytomegalovirus CD200 orthologue (e127) is ...
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2013-10-23ZeitschriftenartikelCytomegalovirus expresses the chemokine homologue vXCL1 capable of attracting XCR1+CD4- dendritic cells Cytomegaloviruses (CMV) have developed various strategies to escape the immune system of the host. One strategy involves the expression of virus-encoded chemokines to modulate the host chemokine network. We have identified ...