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Browsing by Author "Nitsche, Andreas"
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2012-12-11ZeitschriftenartikelComparison of Shedding Characteristics of Seasonal Influenza Virus (Sub)Types and Influenza A(H1N1)pdm09; Germany, 2007–2011 Süß, Thorsten; Remschmidt, Cornelius; Schink, Susanne; Schweiger, Brunhilde; Heider, Alla; Milde, Jeanette; Nitsche, Andreas; Schroeder, Kati; Döllinger, Jörg; Braun, Christian; Haas, Walter; Krause, Gérard; Buchholz, UdoBackground: Influenza viral shedding studies provide fundamental information for preventive strategies and modelling exercises. We conducted a prospective household study to investigate viral shedding in seasonal and ...
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2015-11-10ZeitschriftenartikelComparison of the Cowpox Virus and Vaccinia Virus Mature Virion Proteome: Analysis of the Species- and Strain-Specific Proteome Döllinger, Jörg; Schaade, Lars; Nitsche, AndreasCowpox virus (CPXV) causes most zoonotic orthopoxvirus (OPV) infections in Europe and Northern as well as Central Asia. The virus has the broadest host range of OPV and is transmitted to humans from rodents and other wild ...
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2012-12-30ZeitschriftenartikelComplete Genome Sequence of the English Isolate of Rat Cytomegalovirus (Murid Herpesvirus 8) Ettinger, Jakob; Geyer, Henriette; Nitsche, Andreas; Zimmermann, Albert; Brune, Wolfram; Sandford, Gordon R.; Hayward, Gary S.; Voigt, SebastianThe complete genome of the English isolate of rat cytomegalovirus (RCMV-E) was determined. RCMV-E has a 202,946-bp genome with noninverting repeats but without terminal repeats. Thus, it differs significantly in size and ...
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2015-03-12ZeitschriftenartikelComprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40 Zischka, Melanie; Künne, Carsten T.; Blom, Jochen; Wobser, Dominique; Sakιnç, Türkân; Schmidt-Hohagen, Kerstin; Dabrowski, Piotr Wojtek; Nitsche, Andreas; Hübner, Johannes; Hain, Torsten; Chakraborty, Trinad; Linke, Burkhard; Goesmann, Alexander; Voget, Sonja; Daniel, Rolf; Schomburg, Dietmar; Hauck, Rüdiger; Hafez, Hafez M.; Tielen, Petra; Bender, Jennifer K.; Steglich, Matthias; Nübel, Ulrich; Witte, Wolfgang; Werner, GuidoBackground: Enterococcus faecalis is a multifaceted microorganism known to act as a beneficial intestinal commensal bacterium. It is also a dreaded nosocomial pathogen causing life-threatening infections in hospitalised ...
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2013-02-21ZeitschriftenartikelContact investigation of a case of human novel coronavirus infection treated in a German hospital, October-November 2012 Buchholz, Udo; Müller, Marcel A.; Nitsche, Andreas; Sanewski, A.; Wevering, N.; Bauer-Balci, T.; Bonin, F.; Drosten, Christian; Schweiger, Brunhilde; Wolff, Thorsten; Muth, D.; Meyer, B.; Buda, Silke; Krause, Gérard; Schaade, Lars; Haas, WalterOn 24 October 2012, a patient with acute respiratory distress syndrome of unknown origin and symptom onset on 5 October was transferred from Qatar to a specialist lung clinic in Germany. Late diagnosis on 20 November of ...
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2009-09-03ZeitschriftenartikelCowpox Virus Outbreak in Banded Mongooses (Mungos mungo) and Jaguarundis (Herpailurus yagouaroundi) with a Time-Delayed Infection to Humans Kurth, Andreas; Straube, Martin; Kuczka, Annette; Dunsche, Anton Josef; Meyer, Hermann; Nitsche, AndreasBackground: Often described as an extremely rare zoonosis, cowpox virus (CPXV) infections are on the increase in Germany. CPXV is rodent-borne with a broad host range and contains the largest and most complete genome of ...
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2009-08-22ZeitschriftenartikelCrystallization and preliminary X-ray diffraction data of an LNA 7-mer duplex derived from a ricin aptamer Förster, Charlotte; Oberthuer, Dominik; Gao, Jiang; Eichert, André; Quast, Frederick G.; Betzel, Christian; Nitsche, Andreas; Erdmann, Volker A.; Fürste, Jens P.Locked nucleic acids (LNAs) are modified nucleic acids which contain a modified sugar such as beta-D-2'-O,4'-C methylene-bridged ribofuranose or other sugar derivatives in LNA analogues. The beta-D-2'-O,4'-C methylene ...
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2007-08-31ZeitschriftenartikelCytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors Nitsche, Andreas; Zhang, Meixia; Clauss, Theresa; Siegert, Wolfgang; Brune, Kay; Pahl, AndreasBackground: Stem cell transplantation as therapy for hematological disorders is often hampered by severe graft-versus-host-disease. This may be reduced by umbilical cord blood transplantation, an effect that has been ...
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2021-06-08ZeitschriftenartikelDelayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany Schwarz, Tatjana; Tober-Lau, Pinkus; Hillus, David; Helbig, Elisa T.; Lippert, Lena J.; Thibeault, Charlotte; Koch, Willi; Landgraf, Irmgard; Michel, Janine; Bergfeld, Leon; Niemeyer, Daniela; Mühlemann, Barbara; Conrad, Claudia; Dang-Heine, Chantip; Kasper, Stefanie; Münn, Friederike; Kappert, Kai; Nitsche, Andreas; Tauber, Rudolf; Schmidt, Sein; Kopankiewicz, Piotr; Bias, Harald; Seybold, Joachim; von Kalle, Christof; Jones, Terry C.; Suttorp, Norbert; Drosten, Christian; Sander, Leif Erik; Corman, Victor M.; Kurth, FlorianWe detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize ...
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2021-06-15ZeitschriftenartikelDetection of Alpha- and Betacoronaviruses in Miniopterus fuliginosus and Rousettus leschenaultii, two species of Sri Lankan Bats Muzeniek, Therese; Perera, Thejanee; Siriwardana, Sahan; Bas, Dilara; Kaplan, Fatimanur; Öruc, Mizgin; Becker-Ziaja, Beate; Schwarz, Franziska; Premawansa, Gayani; Premawansa, Sunil; Perera, Inoka; Yapa, Wipula; Nitsche, Andreas; Kohl, ClaudiaBats are known to be potential reservoirs of numerous human-pathogenic viruses. They have been identified as natural hosts for coronaviruses, causing Severe Acute Respiratory Syndrome (SARS) in humans. Since the emergence ...
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2006-07-01ZeitschriftenartikelDetection of Infectious Poxvirus Particles. Nitsche, Andreas; Stern, Daniel; Ellerbrok, Heinz; Pauli, GeorgTo enable rapid and reliable detection of poxviruses in clinical and environmental specimens, a diagnostic approach was developed to detect
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2017-11-20ZeitschriftenartikelDevelopment and preliminary evaluation of a multiplexed amplification and next generation sequencing method for viral hemorrhagic fever diagnostics Brinkmann, Annika; Ergünay, Koray; Radonić, Aleksandar; Tufan, Zeliha Kocak; Domingo, Cristina; Nitsche, AndreasBackground: We describe the development and evaluation of a novel method for targeted amplification and Next Generation Sequencing (NGS)-based identification of viral hemorrhagic fever (VHF) agents and assess the ...
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2016-03-01ZeitschriftenartikelDevelopment of a Genus-Specific Antigen Capture ELISA for Orthopoxviruses – Target Selection and Optimized Screening Stern, Daniel; Pauly, Diana; Zydek, Martin; Miller, Lilija; Piesker, Janett; Laue, Michael; Lisdat, Fred; Dorner, Martin; Dorner, Brigitte; Nitsche, AndreasOrthopoxvirus species like cowpox, vaccinia and monkeypox virus cause zoonotic infections in humans worldwide. Infections often occur in rural areas lacking proper diagnostic infrastructure as exemplified by monkeypox, ...
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2010-04-01ZeitschriftenartikelDiagnostic Approach for the Differentiation of the Pandemic Influenza A(H1N1)v Virus from Recent Human Influenza Viruses by Real-Time PCR Schulze, Martin; Nitsche, Andreas; Schweiger, Brunhilde; Biere, BarbaraBackground: The current spread of pandemic influenza A(H1N1)v virus necessitates an intensified surveillance of influenza virus infections worldwide. So far, in many laboratories routine diagnostics were limited to ...
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2023-06-01ZeitschriftenartikelDirect comparison of clinical diagnostic sensitivity of saliva from buccal swabs versus combined oro-/nasopharyngeal swabs in the detection of SARS-CoV-2 B.1.1.529 Omicron Puyskens, Andreas; Michel, Janine; Stoliaroff-Pepin, Anna; Bayram, Fatimanur; Sesver, Akin; Wichmann, Ole; Harder, Thomas; Schaade, Lars; Nitsche, Andreas; Peine, CarolineBackground/Purpose: While current guidelines recommend the use of respiratory tract specimens for the direct detection of SARS-CoV-2 infection, saliva has recently been suggested as preferred sample type for the ...
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2007-09-06ZeitschriftenartikelDiscovery of herpesviruses in multi-infected primates using locked nucleic acids (LNA) and a bigenic PCR approach Prepens, Sandra; Kreuzer, Karl-Anton; Leendertz, Fabian; Nitsche, Andreas; Ehlers, BernhardTargeting the highly conserved herpes DNA polymerase (DPOL) gene with PCR using panherpes degenerate primers is a powerful tool to universally detect unknown herpesviruses. However, vertebrate hosts are often infected with ...
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2015-07-23ZeitschriftenartikelDraft Genome Sequences of Klebsiella oxytoca Isolates Originating from a Highly Contaminated Liquid Hand Soap Product Hammerl, J. A.; Lasch, Peter; Nitsche, Andreas; Dabrowski, Piotr Wojtek; Hahmann, H.; Wicke, Amal; Kleta, S.; Dahouk, Sascha Al; Dieckmann, R.In 2013, contaminated liquid soap was detected by routine microbiological monitoring of consumer products through state health authorities. Because of its high load of Klebsiella oxytoca, the liquid soap was notified via ...
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2019-09-04ZeitschriftenartikelEffects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study Bellikci-Koyu, Ezgi; Sarer-Yurekli, Banu Pınar; Akyon, Yakut; Aydin-Kose, Fadime; Karagozlu, Cem; Ozgen, Ahmet Gokhan; Brinkmann, Annika; Nitsche, Andreas; Ergunay, Koray; Yilmaz, Engin; Buyuktuncer, ZehraSeveral health-promoting effects of kefir have been suggested, however, there is limited evidence for its potential effect on gut microbiota in metabolic syndrome This study aimed to investigate the effects of regular kefir ...
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2017-11-11ZeitschriftenartikelEquination (inoculation of horsepox): An early alternative to vaccination (inoculation of cowpox) and the potential role of horsepox virus in the origin of the smallpox vaccine Esparza, José; Schrick, Livia; Damaso, Clarissa R.; Nitsche, AndreasFor almost 150 years after Edward Jenner had published the “Inquiry” in 1798, it was generally assumed that the cowpox virus was the vaccine against smallpox. It was not until 1939 when it was shown that vaccinia, the ...
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2021-04-15ZeitschriftenartikelErfassung der Labortestungen auf SARS-CoV-2 in Deutschland Seifried, Janna; Hoffmann, Alexandra; Reda, Sarah; Böttcher, Sindy; Abu Sin, Muna; Hofmann, Alexandra; Noll, Ines; von Laer, Anja; Reuss, Annicka; Oh, Djin-Ye; Albrecht, Stefan; Stern, Daniel; WIllrich, Niklas; Staat, Doreen; Zacher, Benedikt; Schneider, Marc; Feig, Marcel; Nitsche, Andreas; Rieck, Thorsten; Rexroth, Ute; Eckmanns, Tim; Hamouda, OsamahDie Erfassung von Daten zu SARS-CoV-2-Testungen in Deutschland sind für die Einschätzung des Infektionsgeschehens im Rahmen der COVID-19-Pandemie von zentraler Bedeutung. Am Robert Koch-Institut (RKI) werden dazu die Daten ...