Browsing by Title
Now showing items 83-102 of 12040
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2020-10-08ZeitschriftenartikelA decade of de novo transcriptome assembly: Are we there yet? A decade ago, de novo transcriptome assembly evolved as a versatile and powerful approach to make evolutionary assumptions, analyse gene expression, and annotate novel transcripts, in particular, for non‐model organisms ...
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2020-10-08ZeitschriftenartikelA decade of de novo transcriptome assembly: Are we there yet? A decade ago, de novo transcriptome assembly evolved as a versatile and power- ful approach to make evolutionary assumptions, analyse gene expression, and anno- tate novel transcripts, in particular, for non-model organisms ...
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2022-04-30ZeitschriftenartikelA dominant clonal lineage of Streptococcus uberis in cattle in Germany Bovine mastitis causes enormous economic losses in the dairy industry with Streptococcus uberis as one of the most common bacterial pathogens causing clinical and subclinical variations. In most cases mastitis can be cured ...
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2008-05-08ZeitschriftenartikelA European laboratory network for sequence-based typing of methicillin-resistant Staphylococcus aureus (MRSA) as a communication platform between human and veterinary medicine – an update on SeqNet.org
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2017-11-09ZeitschriftenartikelA European network for food-borne parasites (Euro-FBP): meeting report on ‘Analytical methods for food-borne parasites in human and veterinary diagnostics and in food matrices’ Food-borne parasites (FBPs) are a neglected topic in food safety, partly due to a lack of awareness of their importance for public health, especially as symptoms tend not to develop immediately after exposure. In addition, ...
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2022-05-25ZeitschriftenartikelA Federated and Distributed Data Management Infrastructure to Enable Public Health Surveillance from Intensive Care Unit Data The Robert Koch Institute (RKI) monitors the actual number of COVID-19 patients requiring intensive care from aggregated data reported by hospitals in Germany. So far, there is no infrastructure to make use of individual ...
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2016-09-29ZeitschriftenartikelA Field-Deployable Reverse Transcription Recombinase Polymerase Amplification Assay for Rapid Detection of the Chikungunya Virus Background: Chikungunya virus (CHIKV) is a mosquito-borne virus currently transmitted in about 60 countries. CHIKV causes acute flu-like symptoms and in many cases prolonged musculoskeletal and joint pain. Detection of ...
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2016-01-12ZeitschriftenartikelA Follow-Up of the Multicenter Collaborative Study on HIV-1 Drug Resistance and Tropism Testing Using 454 Ultra Deep Pyrosequencing Background: Ultra deep sequencing is of increasing use not only in research but also in diagnostics. For implementation of ultra deep sequencing assays in clinical laboratories for routine diagnostics, intra- and ...
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2013-09-12ZeitschriftenartikelA Food Handler-Associated, Foodborne Norovirus GII.4 Sydney 2012-Outbreak Following a Wedding Dinner, Austria, October 2012 On October 12, 2012, the provincial public health directorate of Salzburg reported a suspected norovirus (NV) outbreak among guests of a wedding-reception. The investigation aimed to confirm the causative agent, to identify ...
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2015-04-09ZeitschriftenartikelA Gateway-Based System for Fast Evaluation of Protein-Protein Interactions in Bacteria Protein-protein interactions are important layers of regulation in all kingdoms of life. Identification and characterization of these interactions is one challenging task of the post-genomic era and crucial for understanding ...
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2021-12-01ZeitschriftenartikelA Genetic Variation of Lipopolysaccharide Binding Protein Affects the Inflammatory Response and Is Associated with Improved Outcome during Sepsis LPS binding protein (LBP) is an important innate sensor of microbial cell wall structures. Frequent functionally relevant mutations exist and have been linked to influence susceptibility to and course of bacterial infections. ...
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2013-01-08ZeitschriftenartikelA genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic The widespread use of antibiotics in association with high-density clinical care has driven the emergence of drug-resistant bacteria that are adapted to thrive in hospitalized patients. Of particular concern are globally ...
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2021-06-24ZeitschriftenartikelA global metagenomic map of urban microbiomes and antimicrobial resistance We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an ...
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2022-09StudienarbeitA health economic evaluation of prostate-specific antigen-based risk-stratified prostate cancer screening strategies in Germany Prostate cancer (PCa) screening remains a controversial topic. The value of population-based screening in reducing premature deaths remains unclear, primarily due to over-diagnosis and overtreatments. However, with an ...
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2017-01-12ZeitschriftenartikelA joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: lessons learnt Molecular surveillance of multidrug-resistant tuberculosis (MDR-TB) using 24-loci MIRU-VNTR in the European Union suggests the occurrence of international transmission. In early 2014, Austria detected a molecular MDR-TB ...
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2022-06-09ZeitschriftenartikelA Joint Regional Analysis of Resistance Combinations in Escherichia coli in Humans and Different Food-Producing Animal Populations in Germany Between 2014 and 2017 A joint comparative regional analysis of different resistance combinations across human and veterinary medicine has not been previously conducted in Germany. This study analyses 16 resistance combinations from four antibiotics ...
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2020-12-09ZeitschriftenartikelA Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition Background Antibiotic-resistant Klebsiella pneumoniae are a major cause of hospital- and community-acquired infections, including sepsis, liver abscess, and pneumonia, driven mainly by the emergence of successful high-risk ...
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2022-09-08ZeitschriftenartikelA large multi-country outbreak of monkeypox across 41 countries in the WHO European Region, 7 March to 23 August 2022 Following the report of a non-travel-associated cluster of monkeypox cases by the United Kingdom in May 2022, 41 countries across the WHO European Region have reported 21,098 cases and two deaths by 23 August 2022. Nowcasting ...
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2017-10-31ZeitschriftenartikelA large proportion of people who inject drugs are susceptible to hepatitis B: Results from a bio-behavioural study in eight German cities Background: People who inject drugs (PWID) are at high risk of hepatitis B virus (HBV) infection by sharing needles and drug use paraphernalia. In Germany, no routine surveillance of HBV prevalence and vaccination ...
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2018-05-02ZeitschriftenartikelA lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. ...