Auflistung nach Schlagwort "HIV-1"
Anzeige der Publikationen 1-20 von 22
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2019-03-04ZeitschriftenartikelCharacterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o Background HCV exhibits a high genetic diversity and is classified into 7 genotypes which are further divided into 86 confirmed subtypes. However, there are multiple isolates with unassigned subtypes. We aimed to amplify ...
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2009-05-01DiplomarbeitEinfluss des immunsuppressiven Peptids von HIV-1 auf die Genexpression in humanen Immunzellen Wie die meisten Retroviren, ruft auch HIV-1 eine Immunsuppression in Infizierten hervor. Es gibt Hinweise darauf, dass das transmembrane Hüllprotein gp41 und dessen hoch konservierte immunsuppressive (ISU-) Domäne an der ...
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2009-06-01DiplomarbeitExpression rekombinanter, von HIV-1 gp41 abgeleiteter Proteine für die Analyse der Immunpathogenese Zur Etablierung eines Endotoxin-freien Bacillus megaterium Produktionssystems wurden zehn mittels PCR amplifizierte, von HIV-1 g41 abgeleitete Fragmente hergestellt und in transformations-kompetente B. megaterium Protoplasten ...
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2011-12-01MasterarbeitFoamy virus Bet fusion proteins for induction of neutralising antibodies against HIV-1 Seit der Entdeckung des HI Virus in den frühen 1980iger Jahren, spiegelt die von ihm ausgelöste AIDS Pandemie mit mehr als 30 Millionen Toten weltweit eine der ernstzunehmensten Krankheiten unserer Zeit wieder. Trotz ...
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2012-09-17DissertationHIV-1 Resistenzentwicklung nach Einsatz antiretroviraler Medikamentenregime zur Prävention der Mutter-Kind-Übertragung von HIV in Uganda und Tansania Subsahara-Afrika ist die weltweit am stärksten betroffene Region von HIV/AIDS. Im Jahr 2010 entfielen ca. 68% aller HIV-Infektionen und 90% der HIV-Neuinfektionen bei Kindern (
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2015-01-16DissertationHIV-1 vaccine epitope delivery based on foamy viral hybrid proteins and vectors Die Induktion neutralisierender Antikörper durch Vakzinierung ist eine der attraktivsten Strategien, um eine nachfolgende Infektion durch Viren zu verhindern. Während jedoch solche Antikörper die Basis für viele bestehende ...
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2013-02-26ZeitschriftenartikelImmunisation with foamy virus Bet fusion proteins as novel strategy for HIV-1 epitope delivery The induction of 2F5- and 4E10-like antibodies broadly neutralising HIV-1 and targeting the membrane external proximal region (MPER) of the transmembrane envelope protein gp41 would be a major advancement for the development ...
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2007-02-28DiplomarbeitImmunisierungsstudien mit vom transmembranen Hüllprotein gp41 von HIV-1 abgeleiteten Hybridproteinen Die Entwicklung effektiver Impfstoffe gegen Infektionskrankheiten wie AIDS ist eines der Hauptziele der Biowissenschaften. Eine Impfung wäre die kostengünstigste Möglichkeit zu Eindämmung von HIV und auch mit weniger ...
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2014-07-21ZeitschriftenartikelIncrease in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe Background: One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data ...
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2012-11-05ZeitschriftenartikelIncreased titers of neutralizing antibodies after immunization with both envelope proteins of the porcine endogenous retroviruses (PERVs) Despite enormous difficulties to induce antibodies neutralizing HIV-1, especially broadly neutralizing antibodies directed against the conserved membrane proximal external region (MPER) of the transmembrane envelope protein, ...
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2018-11-08ZeitschriftenartikelIncreasing proportions of HIV-1 non-B subtypes and of NNRTI resistance between 2013 and 2016 in Germany: Results from the national molecular surveillance of new HIV-diagnoses Background Molecular surveillance of newly diagnosed HIV-infections is important for tracking trends in circulating HIV-variants, including those with transmitted drug resistances (TDR) to sustain ART efficacy. Methods Dried ...
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2012-08-22ZeitschriftenartikelInduction of Antibodies Specific for Gp41 of HIV-1 by Gene Gun DNA Vaccination All attempts to induce broadly neutralising antibodies such as mAb 2F5 and mAb 4E10 targeting conserved epitopes in the membrane proximal external region (MPER) of the transmembrane envelope (TM) protein gp41 of HIV-1 ...
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2008-09-01DiplomarbeitInteraktion des transmembranen Hüllproteins von HIV-1 mit humanen Immunzellen Infektionen mit HIV und anderen Retroviren sind durch eine starke Unterdrückung des Immunsystems charakterisiert. Der Mechanismus der Auslösung dieser Immunsuppression ist noch weitgehend unbekannt. Es gibt erste Hinweise ...
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2013-04-03ZeitschriftenartikelLimited cross-border infections in patients newly diagnosed with HIV in Europe Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections ...
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2017-03-19ZeitschriftenartikelMutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in 20% to 60% of individuals with virological failure (VF) on a WHO-recommended TDF-containing first-line regimen. However, ...
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2011-09-24ZeitschriftenartikelOptimisation of expression and purification of the feline and primate foamy virus transmembrane envelope proteins using a 96 deep well screen The production of recombinant transmembrane proteins is due to their biochemical properties often troublesome and time consuming. Here the prokaryotic expression and purification of the transmembrane envelope proteins of ...
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2022-03-16ZeitschriftenartikelPhylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load Set-point viral load (SPVL), a common measure of human immunodeficiency virus (HIV)-1 virulence, is partially determined by viral genotype. Epidemiological evidence suggests that this viral property has been under stabilising ...
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2013-11-14ZeitschriftenartikelSymptomatic Illness and Low CD4 Cell Count at HIV Seroconversion as Markers of Severe Primary HIV Infection Background: The risk/benefit of initiating ART in primary HIV infection (PHI) is unclear. The benefits are more likely to outweigh the risks in patients with severe PHI. An accepted definition of severe PHI is, however, ...
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2016-06-02ZeitschriftenartikelThe global spread of HIV-1 subtype B epidemic Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B ...
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2014-03-01BachelorarbeitThe Role of CD63-Large Extracellular Loop on HIV-1 entry and cell to cell transfer Regarding to the World Health Organization’s 2011 published list of the top ten causes of death worldwide, HIV/ AIDS is still listed as the 6th most frequent reason for fatality. Previous analyses with a Yeast two-hybrid ...