2010-11-11Zeitschriftenartikel
Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE
Gültner, Sandra; Kuhlmann, Tanja; Hesse, Amke; Weber, Jan P.; Riemer, Constanze; Baier, Michael; Hutloff, Andreas
The αLβ2-integrin LFA-1 (CD11a/CD18) is known as an important molecule for leukocyte migration. However, the precise role of LFA-1 in the pathogenesis of EAE has so far remained unclear. We describe here the disease ...