Browsing by Subject "RNA"
Now showing items 1-20 of 20
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2013-07-16ZeitschriftenartikelA Mouse Model for Human Norovirus Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since "humanized" mice have been successfully ...
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2009-03-01ZeitschriftenartikelCoordinated Implementation of Chikungunya Virus Reverse Transcription–PCR. A preformulated chikungunya virus real-time reverse transcription-PCR, quality-confirmed oligonucleotides, and noninfectious virus controls were distributed by the European Network for the Diagnosis of Imported Viral ...
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2007-08-31ZeitschriftenartikelCytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors Background: Stem cell transplantation as therapy for hematological disorders is often hampered by severe graft-versus-host-disease. This may be reduced by umbilical cord blood transplantation, an effect that has been ...
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2008-12-03ZeitschriftenartikelDetection of Balamuthia mandrillaris DNA by real-time PCR targeting the RNase P gene Background: The free-living amoeba Balamuthia mandrillaris may cause fatal encephalitis both in immunocompromised and in – apparently – immunocompetent humans and other mammalian species. Rapid, specific, sensitive, and ...
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2009-05-14ZeitschriftenartikelDetection of hepatitis E virus in wild boars of rural and urban regions in Germany and whole genome characterization of an endemic strain Background: Hepatitis E is an increasingly diagnosed human disease in Central Europe. Besides domestic pigs, in which hepatitis E virus (HEV) infection is highly prevalent, wild boars have been identified as a possible ...
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2006-07-01ZeitschriftenartikelDetection of Infectious Poxvirus Particles. To enable rapid and reliable detection of poxviruses in clinical and environmental specimens, a diagnostic approach was developed to detect
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2006-04-10ZeitschriftenartikelDetection of Norovirus genogroup I and II by multiplex real-time RT- PCR using a 3'-minor groove binder-DNA probe Background: Due to an increasing number of norovirus infections in the last years rapid, specific, and sensitive diagnostic tools are needed. Reverse transcriptase-polymerase chain reactions (RT-PCR) have become the methods ...
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2009-04-22ZeitschriftenartikelDistribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation Background: Multi-transgenic pigs produced for use in xenotransplantation have to be screened for the presence and expression of porcine endogenous retroviruses (PERV) to select animals with low PERV load. The production ...
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2009-11-01ZeitschriftenartikelEpidemiology of Hepatitis A Virus Infections, 2007-2008 Approximately 60% of hepatitis A virus infections in Germany occur in persons without a travel history to disease-endemic areas and for whom sources of infection are unknown. Recommendation of pretravel vaccination fails ...
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2009-03-01ZeitschriftenartikelImmunogenicity and Safety of Yellow Fever Vaccination for 102 HIV‐Infected Patients Background: Yellow fever vaccine (17DV) has been investigated incompletely in human immunodeficiency virus (HIV)–infected patients, and adequate immunogenicity and safety are of concern in this population. Methods: In ...
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2008-11-07ZeitschriftenartikelInfluenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression The type I interferon (IFN) system is a first line of defense against viral infections. Viruses have developed various mechanisms to counteract this response. So far, the interferon antagonistic activity of influenza A ...
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2009-06-12ZeitschriftenartikelInfluenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR Activation of the latent kinase PKR is a potent innate defense reaction of vertebrate cells towards viral infections, which is triggered by recognition of viral double-stranded (ds) RNA and results in a translational ...
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2008-03-10ZeitschriftenartikelKnockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs Background: Xenotransplantation using porcine cells, tissues or organs may be associated with the transmission of porcine endogenous retroviruses (PERVs). More than 50 viral copies have been identified in the pig genome ...
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2009-10-16ZeitschriftenartikelLack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients Background: A novel gammaretrovirus named xenotropic murine leukemia virus-related virus (XMRV) has been recently identified and found to have a prevalence of 40% in prostate tumor samples from American patients carrying ...
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2003-02-01ZeitschriftenartikelNosocomial Transmission of Hepatitis C Virus Associated With the Use of Multidose Saline Vials Objective: To identify the source of an outbreak of acute hepatitis C virus (HCV) infection among 3 patients occurring within 8 weeks of hospitalization in the same ward of a Florida hospital during November 1998. Design: ...
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2010-08-25ZeitschriftenartikelNS Reassortment of an H7-Type Highly Pathogenic Avian Influenza Virus Affects Its Propagation by Altering the Regulation of Viral RNA Production and Antiviral Host Response Highly pathogenic avian influenza viruses (HPAIV) with reassorted NS segments from H5- and H7-type avian virus strains placed in the genetic background of the A/FPV/Rostock/34 HPAIV (FPV; H7N1) were generated by reverse ...
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2010-09-14ZeitschriftenartikelPhylogenetic history demonstrates two different lineages of dengue type 1 virus in Colombia Background: Dengue Fever is one of the most important viral re-emergent diseases affecting about 50 million people around the world especially in tropical and sub-tropical countries. In Colombia, the virus was first ...
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2022-03-28ZeitschriftenartikelShort- and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging RNA dimerization is the noncovalent association of two human immunodeficiency virus-1 (HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a prerequisite for binding to the viral structural ...
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2008-11-19ZeitschriftenartikelSpecific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143 Double-stranded RNA (dsRNA) produced during viral infection activates several cellular antiviral responses. Among the best characterized is the shutoff of protein synthesis mediated by the dsRNA-dependent protein kinase ...
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2010-06-01ZeitschriftenartikelXenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory Tract Xenotropic murine leukemia virus–related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using ...